A map of fear | Nature Reviews Genetics

Access through your institution Buy or subscribe Mott _et al_. report a solution to the twofold problem of stock homogeneity and the need for a finer QTL mapping resolution. Their improved

technique is illustrated by mapping five QTL for emotionality in mice. The classical way of mapping QTL involves crossing two inbred lines that differ in the mean phenotype of a given trait.

Repeated intercrosses or backcrosses onto one parental strain are then conducted to single out the regions with the QTL from the rest of the genome. To increase the resolution in QTL

mapping, Mott _et al_. abandoned simple crosses between inbred lines in their mapping studies in favour of a genetically heterogeneous stock, which was established 30 years ago from eight

inbred founder strains. The highly recombinant nature of the heterogeneous stock genome (which is a fine genetic mosaic of its founders) gives a 30-fold increase in the resolution for QTL

mapping, allowing mapping of QTL to under 0.5 cM with fewer than 2,000 animals. Because the heterogeneous stock was derived from eight different lines, it is also genetically diverse. This

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during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support ORIGINAL RESEARCH PAPER * Mott, R. et al. A method

for fine mapping quantitative trait loci in outbred animal stocks. _Proc. Natl Acad. Sci. USA_ 97, 12649–12654 (2000) Article  PubMed  PubMed Central  Google Scholar  Download references

Authors * Tanita Casci View author publications You can also search for this author inPubMed Google Scholar RELATED LINKS RELATED LINKS WEB SITE Jonathan Flint's lab Software analysis

RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Casci, T. A map of fear. _Nat Rev Genet_ 2, 8 (2001). https://doi.org/10.1038/35047515 Download citation

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