Infection of rabbits with human immunodeficiency virus

ABSTRACT An important requirement for the development of a vaccine against the human immunodeficiency virus (HIV-1)1, the causative agent of AIDS2, is a readily available animal model that

would allow possible immunogens to be evaluated3. The only species to have been infected with HIV-1 so far is the chimpanzee4–7. However, the scarcity of this animal and its designation as

an endangered species8 place severe restrictions on its use as an animal model. Attempts to infect mice, rats, hamsters, guinea-pigs, musk shrews, and rabbits with HIV-1 or infected cells

have all been unsuccessful9. We now report that the intraperitoneal inoculation of rabbits with HIV-1 or chronically infected H9 cells consistently induces a persistent infection. Access

through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal

Receive 51 print issues and online access $199.00 per year only $3.90 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may

be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support

SIMILAR CONTENT BEING VIEWED BY OTHERS ADJUVANT FORMULATED VIRUS-LIKE PARTICLES EXPRESSING NATIVE-LIKE FORMS OF THE LASSA VIRUS ENVELOPE SURFACE GLYCOPROTEIN ARE IMMUNOGENIC AND INDUCE

ANTIBODIES WITH BROADLY NEUTRALIZING ACTIVITY Article Open access 04 August 2020 LONG-TERM PROTECTIVE IMMUNITY INDUCED BY AN ADJUVANT-CONTAINING LIVE-ATTENUATED AIDS VIRUS Article Open

access 22 October 2021 ENHANCING ANTI-VIRAL NEUTRALIZATION RESPONSE TO IMMUNIZATION WITH HIV-1 ENVELOPE GLYCOPROTEIN IMMUNOGENS Article Open access 24 November 2023 REFERENCES *

Barré-Sinoussi, F. _et al._ _Science_ 220, 868–871 (1983). Article  ADS  Google Scholar  * Gallo, R. C. _et al._ _Science_ 224, 500–503 (1984). Article  ADS  CAS  Google Scholar  * Matthews,

T. J. _et al._ _AIDS Res. Hum. Relrovimses_ 3, 197–206 (1987). Article  CAS  Google Scholar  * Alter, H. J. _et al._ _Science_ 226, 549–552 (1984). Article  ADS  CAS  Google Scholar  *

Gajdusek, D. C. _et al._ _Lancet_ I, 55–56 (1985). Article  Google Scholar  * Fultz, P. N. _et al._ _J. Virol._ 58, 116–124 (1986). CAS  PubMed  PubMed Central  Google Scholar  * Fultz, P.

N. _et al._ _J. infect. Dis._ 154, 896–900 (1986). Article  CAS  Google Scholar  * Desrosiers, R. C. & Letvin, N. L. _Rev. Infect. Dis._ 9, 438–446 (1987). Article  CAS  Google Scholar 

* Morrow, W. J. W., Whaton, M., Lan, D. & Levy, J. A. _J. gen. Virol._ 68, 2253–2257 (1987). Article  Google Scholar  * Popovic, M., Sarngadharan, M. G., Read, E. & Gallo, R. C.

_Science_ 224, 497–500 (1984). Article  ADS  CAS  Google Scholar  * Cereda, P. M., Debiaggi, M. & Romero, E. _Microbiologica_ 7, 107–111 (1984). CAS  PubMed  Google Scholar  * Mullis, K.

& Faloona, F. A. _Cold Spring Harb. Symp. quant. Biol._ 51, 263–273 (1986). Article  CAS  Google Scholar  * Gartner, S. _et al._ _Science_ 233, 215–219 (1986). Article  ADS  CAS  Google

Scholar  * Äsjö, B. _et al._ _Virology_ 157, 359–365 (1987). Article  Google Scholar  * Clapham, P. R. _et al._ _Virology_ 158, 44–51 (1987). Article  CAS  Google Scholar  * Kotani, S. _et

al._ _Int. J. Cancer_ 37, 843–847 (1986). Article  CAS  Google Scholar  * Kulaga, H., Folks, T. M., Rutledge, R. & Kindt, T. J. _Proc. natn. Acad. Sci. U.S.A._ 85, 4455–4459 (1988).

Article  ADS  CAS  Google Scholar  * Poiesz, B. J. _et al._ _Proc. natn. Acad. Sci. U.S.A._ 77, 7415–7419 (1980). Article  ADS  CAS  Google Scholar  * Davis, L. G. _et al._ in _Basic Methods

in Molecular Biology_ 44–46 (Elsevier, New York, 1986). Book  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Institute of Infectious Diseases, IRCCS

"San Matteo", School of Medicine, 27100, Pavia, Italy Gaetano Filice * Institute of Microbiology, School of Medicine, 27100, Pavia, Italy Paolo M. Cereda * Laboratory of Human

Retrovirology, Institute of Microbiology, School of Medicine, 16132, Geneva, Italy Oliviero E. Varnier Authors * Gaetano Filice View author publications You can also search for this author

inPubMed Google Scholar * Paolo M. Cereda View author publications You can also search for this author inPubMed Google Scholar * Oliviero E. Varnier View author publications You can also

search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Filice, G., Cereda, P. & Varnier, O. Infection of

rabbits with human immunodeficiency virus. _Nature_ 335, 366–369 (1988). https://doi.org/10.1038/335366a0 Download citation * Received: 13 June 1988 * Accepted: 11 August 1988 * Issue Date:

22 September 1988 * DOI: https://doi.org/10.1038/335366a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable

link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative