Therapeutic application of t cell receptor mimic peptides or cdna in the treatment of t cell-mediated skin diseases

ABSTRACT An 8-amino acid peptide encoding a sequence of the transmembrane region of the T cell receptor α chain (TCR-α) was shown to inhibit T cell function by preventing functional assembly

of the T cell receptor (mimic peptide). To avoid systemic immunosuppression by peptide application in vivo, we used a topical application of the peptide. In the system of murine contact

sensitivity, topical application of the peptide inhibited the elicitation of contact sensitivity following application of a contact allergen in sensitized animals. Alternatively, when naked

DNA encoding the peptide sequence was injected into skin before application of a contact allergen to sensitized animals, local immunosuppression was also observed. To investigate the effects

of this peptide in humans, patients with psoriasis, atopic eczema, lichen planus, or contact dermatitis were treated topically with mimic peptide or control peptide. All patients except for

one reported a marked improvement or cure of their skin disease following application of the TCR-α peptide, but not controls. These data indicate that TCR-α peptide or cDNA treatment might

be a proper treatment for human T cell-mediated dermatoses substituting for corticosteroids. Access through your institution Buy or subscribe This is a preview of subscription content,

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OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS CD1A PROMOTES SYSTEMIC MANIFESTATIONS OF SKIN

INFLAMMATION Article Open access 07 December 2022 CTLA-4 SUPPRESSES HAPTEN-INDUCED CONTACT HYPERSENSITIVITY IN ATOPIC DERMATITIS MODEL MICE Article Open access 16 May 2023 DITHRANOL AS NOVEL

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CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Dermatology, University of Mainz, Mainz, 55131, Germany GP Göllner, G Müller, R Alt, J

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ARTICLE CITE THIS ARTICLE Göllner, G., Müller, G., Alt, R. _et al._ Therapeutic application of T cell receptor mimic peptides or cDNA in the treatment of T cell-mediated skin diseases. _Gene

Ther_ 7, 1000–1004 (2000). https://doi.org/10.1038/sj.gt.3301183 Download citation * Received: 08 November 1999 * Accepted: 25 January 2000 * Published: 14 June 2000 * Issue Date: 01 June

2000 * DOI: https://doi.org/10.1038/sj.gt.3301183 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is

not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * TCR * T cell function * allergical contact

dermatitis * T cell mediated disease * DNA vaccination