The third component of complement (c3) is responsible for the intracellular survival of leishmania major


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ABSTRACT _Leishmania_ are obligate intracellular parasites of mononuclear phagocytes. We 1,2 and others3 have shown that the promastigote form of all species of leishmania activates


complement from non-immune serum and that this activation can result in parasite lysis. This work, as well as earlier _in vivo_ studies4, suggested that complement is an important component


of host defence against leishmaniasis. We now present evidence that parasite complement fixation, in addition to increasing parasite phagocytosis5,6, is required for the intracellular


survival of leishmania in macrophages. We specifically show a strong correlation between parasite C3 fixation and intracellular survival. We attribute this survival, in part, to a decrease


in the magnitude of the macrophage respiratory burst which is triggered by complement-coated, as opposed to uncoated, parasites. Access through your institution Buy or subscribe This is a


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Article 11 January 2021 REFERENCES * 1. Mosser, D. M. & Edelson, P. J. /. Immun. 132, 1501–1505 (1984). 2. Mosser, D. M., Burke, S. K., Coutavas, E. E., Wedgwood, J. F. & Edelson,


P. J. Expl Parasitol. 62, 394–404 (1986). 3. Pearson, R. D. & Steigbigel, R. T. /. Immun. 125, 2195–2201 (1980). 4. Poulter, L. W. Clin. exp. Immun. 40, 25–35 (1980). 5. Mosser, D. M.


& Edelson, P. J. / Immun. 135, 2785–2789 (1985). 6. Blackwell, J. M. et al J. exp. Med. 162, 324–331 (1985). 7. Mosser, D. M., Wedgwood, J. F. & Edelson, P. J. / Immun. 134,


4128–4131 (1985). 8. Lachmann, P. J., Pangburn, M. K. & Oldroyd, R. G. / exp. Med. 156, 205–216 (1982). 9. Murray, H. W. & Cartelli, D. M. J. din. Invest. 72, 32–44 (1983). 10.


Pearson, R. D. & Steigbigel, R. T. /. Immun. 127, 1438–1443 (1981). 11. Wright, S. D. & Silverstein, S. C. /. exp. Med. 158, 2016–2023 (1983). 12. Pantasis, C. & Knicker, W. T.


J. Reticuloendothel. Soc. 26, 155–170 (1979). 13. Johnston, R. B., Godzik, C. A. & Cohn, Z. A. /. exp. Med. 148, 115–127 (1978). Download references AUTHOR INFORMATION AUTHORS AND


AFFILIATIONS * Department of Pediatrics, Division of Infectious Diseases andImmunology, New York Hospital and Cornell University Medical College, New York, New York, USA David M. Mosser 


& Paul J. Edelson Authors * David M. Mosser View author publications You can also search for this author inPubMed Google Scholar * Paul J. Edelson View author publications You can also


search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Mosser, D., Edelson, P. The third component of complement


(C3) is responsible for the intracellular survival of _Leishmania major_. _Nature_ 327, 329–331 (1987). https://doi.org/10.1038/327329b0 Download citation * Received: 12 March 1987 *


Accepted: 07 April 1987 * Issue Date: 28 May 1987 * DOI: https://doi.org/10.1038/327329b0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get


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