Organization and evolution of the class i gene family in the major histocompatibility complex of the c57bl/10 mouse


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ABSTRACT The major histocompatibility complex (MHC) encodes several classes of protein vital to the regulation of the immune response. We have isolated 26 class I genes that map to this


region in the C57BL/10 mouse and linked these into three gene clusters. The number of genes differs from the number found in the BALB/c strain and comparison of the organization of the class


I genes in these two strains shows conserved regions and polymorphic regions which probably result from deletions, insertions and translocations within the MHC. Access through your


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Cambridge Center, Cambridge, Massachusetts, 02142, USA Elisabeth H. Weiss, Lynn Golden, Karen Fahrner, Andrew L. Mellor, James J. Devlin, Harm Tiddens & Richard A. Flavell * Laboratory


of Gene Structure and Expression, National Institute for Medical Research, Mill Hill, London, NW7 1AA, UK Elisabeth H. Weiss, Lynn Golden, Andrew L. Mellor, Hilary Bullman, Harriet Bud &


 Richard A. Flavell Authors * Elisabeth H. Weiss View author publications You can also search for this author inPubMed Google Scholar * Lynn Golden View author publications You can also


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publications You can also search for this author inPubMed Google Scholar * James J. Devlin View author publications You can also search for this author inPubMed Google Scholar * Hilary


Bullman View author publications You can also search for this author inPubMed Google Scholar * Harm Tiddens View author publications You can also search for this author inPubMed Google


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inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Weiss, E., Golden, L., Fahrner, K. _et al._ Organization and evolution of the


class I gene family in the major histocompatibility complex of the C57BL/10 mouse. _Nature_ 310, 650–655 (1984). https://doi.org/10.1038/310650a0 Download citation * Received: 21 February


1984 * Accepted: 25 May 1984 * Issue Date: 23 August 1984 * DOI: https://doi.org/10.1038/310650a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this


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