Ca2+-activated atpase and atp-dependent calmodulin-stimulated ca2+ transport in islet cell plasma membrane


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ABSTRACT Calcium is known to play an essential part in the regulation of insulin secretion in the pancreatic _β_ cell1,2. Calcium influx/efflux studies indicate that glucose promotes an


accumulation of calcium by the _β_ cell2. However, interpretation of such data is particularly difficult due to the complex compartmentalization of calcium within the cell. Although indirect


evidence using chlorotetracycline suggests that control of calcium homeostasis at the plasma membrane may be central to insulin secretion3, the mechanism by which secretagogues influence


the handling of calcium remains unknown. Despite its continuous diffusive entry, intracellular calcium is maintained in the submicromolar range4,5 by energy-dependent mechanisms5–9. One such


process which has been well characterized in erythrocytes is a plasma membrane calcium extrusion pump whose enzymatic basis is a high affinity (Ca2+ + Mg2+) ATPase9. A similar


mechanism10,11 regulated by insulin12,13 has recently been identified in adipocyte plasma membranes. We report here the presence of a high affinity (Ca2+ + Mg2+) ATPase and ATP-dependent


calmodulin-stimulated calcium transport system in rat pancreatic islet cell plasma membranes14. Access through your institution Buy or subscribe This is a preview of subscription content,


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INTRACELLULAR Β-CELL CA2+ SIGNALS Article Open access 21 May 2021 5-IP7 IS A GPCR MESSENGER MEDIATING NEURAL CONTROL OF SYNAPTOTAGMIN-DEPENDENT INSULIN EXOCYTOSIS AND GLUCOSE HOMEOSTASIS


Article 18 October 2021 READILY RELEASABLE Β CELLS WITH TIGHT CA2+–EXOCYTOSIS COUPLING DICTATE BIPHASIC GLUCOSE-STIMULATED INSULIN SECRETION Article 26 January 2024 REFERENCES * Grodsky, G.


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references AUTHOR INFORMATION Author notes * Harrihar A. Pershadsingh Present address: University of Missouri-Columbia, School of Medicine, Columbia, Missouri, 65212 AUTHORS AND AFFILIATIONS


* Division of Laboratory Medicine, Departments of Pathology and Medicine, Washington University School of Medicine, St Louis, Missouri, 63110 Harrihar A. Pershadsingh, Michael L. McDaniel, 


Michael Landt, Cheryl G. Bry, Paul E. Lacy & Jay M. McDonald Authors * Harrihar A. Pershadsingh View author publications You can also search for this author inPubMed Google Scholar *


Michael L. McDaniel View author publications You can also search for this author inPubMed Google Scholar * Michael Landt View author publications You can also search for this author inPubMed


 Google Scholar * Cheryl G. Bry View author publications You can also search for this author inPubMed Google Scholar * Paul E. Lacy View author publications You can also search for this


author inPubMed Google Scholar * Jay M. McDonald View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT


THIS ARTICLE CITE THIS ARTICLE Pershadsingh, H., McDaniel, M., Landt, M. _et al._ Ca2+-activated ATPase and ATP-dependent calmodulin-stimulated Ca2+ transport in islet cell plasma membrane.


_Nature_ 288, 492–495 (1980). https://doi.org/10.1038/288492a0 Download citation * Received: 28 April 1980 * Accepted: 29 September 1980 * Issue Date: 04 December 1980 * DOI:


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