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ABSTRACT A variety of normal and transformed avian and mammalian cells and tissues contain high affinity specific receptors on their membranes which interact with biologically active phorbol
and ingenol esters in a reversible and saturable manner. The binding of labelled phorbol-12,13-dibutyrate (PDBu) to live or glutaraldehyde-fixed cells is dose-, time- and
temperature-dependent. Those phorbol or ingenol esters which stimulate cell growth in culture and have tumour-promoting activity _in vivo_ inhibit the binding of labelled PDBu, while the
biologically inactive derivatives fail to do so. Other non-diterpene tumour-promoting agents, epidermal growth factor (EGF), retinoids and prostaglandins do not compete for the binding of
labelled PDBu to its specific membrane receptors. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS
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institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS EXPRESSION OF G PROTEIN-COUPLED RECEPTOR GPR19 IN NORMAL AND NEOPLASTIC HUMAN
TISSUES Article Open access 03 November 2023 DIFFERENTIAL EFFECTS OF STRUCTURALLY DIFFERENT LYSOPHOSPHATIDYLETHANOLAMINE SPECIES ON PROLIFERATION AND DIFFERENTIATION IN PRE-OSTEOBLAST
MC3T3-E1 CELLS Article Open access 02 January 2025 THE RECEPTOR PTPRU IS A REDOX SENSITIVE PSEUDOPHOSPHATASE Article Open access 26 June 2020 REFERENCES * Van Duuren, B. L. _Prog. exp.
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references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Laboratory of Viral Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20205 Mohammed
Shoyab & George J. Todaro Authors * Mohammed Shoyab View author publications You can also search for this author inPubMed Google Scholar * George J. Todaro View author publications You
can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Shoyab, M., Todaro, G. Specific high affinity
cell membrane receptors for biologically active phorbol and ingenol esters. _Nature_ 288, 451–455 (1980). https://doi.org/10.1038/288451a0 Download citation * Received: 04 May 1980 *
Accepted: 25 July 1980 * Issue Date: 04 December 1980 * DOI: https://doi.org/10.1038/288451a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content:
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