Evidence that cyclic gmp regulates membrane potential in rod photoreceptors


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ABSTRACT CYCLIC NUCLEOTIDES have been proposed as mediators of the decreased Na+ permeability caused by illumination of vertebrate photoreceptors1,2. We show here that cyclic GMP depolarises


the rod outer segment (ROS) approximately to the Na+ equilibrium potential within milliseconds after being injected intracellularly, that previous light adaptation antagonises this


depolarisation, and that the injection of cyclic GMP without illumination initiates a repolarisation after a time lag which is longer than that following a light flash and proportional to


the injection time. The results are interpreted in terms of a model in which cyclic GMP levels are controlled by the resultant of cyclase and phosphodiesterase (PDE) velocities. The PDE


velocity of hydrolysis in the dark is increased by prior light adaptation in the presence of increased substrate (cyclic GMP). The data suggest that cyclic GMP is an important factor in the


regulation of the membrane potential of the ROS. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access


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subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS FUNCTIONAL MODULATION OF PHOSPHODIESTERASE-6 BY CALCIUM IN MOUSE ROD PHOTORECEPTORS Article


Open access 26 April 2021 A LIGHT-GATED CATION CHANNEL WITH HIGH REACTIVITY TO WEAK LIGHT Article Open access 10 May 2023 EML1 IS ESSENTIAL FOR RETINAL PHOTORECEPTOR MIGRATION AND SURVIVAL


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Gold, G. H. _J. Neurophysiol._ 42, 311–327 (1979). Article  CAS  PubMed  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Departments of Opthalmology and


Visual Science, and Physiology, Yale University School of Medicine, New Haven, Connecticut, 06510 WILLIAM H. MILLER & GRANT D. NICOL Authors * WILLIAM H. MILLER View author publications


You can also search for this author inPubMed Google Scholar * GRANT D. NICOL View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS


Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE MILLER, W., NICOL, G. Evidence that cyclic GMP regulates membrane potential in rod photoreceptors. _Nature_ 280, 64–66 (1979).


https://doi.org/10.1038/280064a0 Download citation * Received: 17 April 1979 * Accepted: 18 May 1979 * Issue Date: 05 July 1979 * DOI: https://doi.org/10.1038/280064a0 SHARE THIS ARTICLE


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