Autoimmume and polyclonal b cell responses during murine malaria

ABSTRACT INTRACELLULAR protozoan infections of humans and rodents are often characterised by marked hypergamma-globulinaemia reflecting extensive activation of host B lymphocytes. In

addition, the immunoglobulin (Ig) produced is directed not only against parasite antigens but also against a variety of unrelated antigenic determinants, and in some cases has been shown to

contain antibodies reactive to certain host components (reviewed in refs 1 and 2). These findings have led to the suggestion that the infectious organisms may possess nonspecific or

polyclonal activating properties3. Indeed, direct evidence for such mitogenic factors prepared from malarious mouse red blood cells (MRBC) has recently been obtained4. However, in most of

these studies the use of serological or proliferative assays has provided only limited information on the different mechanisms whereby B cells are stimulated to produce antibody during the

course of infection. I report here the use of plaque-forming cell (PFC) assays to reveal the patterns of both total and antigen-specific splenic B lymphocyte activation and also to define in

more detail an anti-erythrocytic autoimmune response following malaria infection of mice. The results demonstrate that a specific, well-defined anti-erythrocytic response occurs shortly

after infection which can be distinguished from, and induced independently of, a very large nonspecific polyclonal response. Both these responses are shown to be T-cell dependent. Access

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SIMILAR CONTENT BEING VIEWED BY OTHERS ΓΔ T CELLS SUPPRESS _PLASMODIUM FALCIPARUM_ BLOOD-STAGE INFECTION BY DIRECT KILLING AND PHAGOCYTOSIS Article 11 January 2021 INTERFERON-Γ SIGNAL DRIVES

DIFFERENTIATION OF T-BETHI ATYPICAL MEMORY B CELLS INTO PLASMA CELLS FOLLOWING _PLASMODIUM VIVAX_ INFECTION Article Open access 22 March 2022 AGE-DEPENDENT CHANGES IN CIRCULATING TFH CELLS

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Diseases, National Institute of Health, Bethesda, Maryland, 20014 YVONNE J. ROSENBERG Authors * YVONNE J. ROSENBERG View author publications You can also search for this author inPubMed 

Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE ROSENBERG, Y. Autoimmume and polyclonal B cell responses during murine malaria. _Nature_

274, 170–172 (1978). https://doi.org/10.1038/274170a0 Download citation * Received: 06 February 1978 * Accepted: 05 May 1978 * Issue Date: 13 July 1978 * DOI:

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