Identification of non-proliferating cells in melanoma b16 tumour


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ABSTRACT THE detection of growth fraction and the characterisation of non-proliferating cells are extremely important in human tumour therapy1,2. Cytological criteria for individual


objective discrimination _in vivo_ between non-proliferating and proliferating cells with the same DNA content have not been previously available3. It has been shown recently, _in vitro_,


that the transition from the non-proliferating to proliferating state (G0—G1) of WI-38 cells—human diploid fibroblasts—can be objectively characterised in the intact cell by flow


microfluiorimetry4 and geometric–densitometric texture analysis5. Similar differences in nuclear morphometry and chromatin conformation between proliferating G1 and non-proliferating ‘G0 +


Q’ cells are reported here for the first time for tumour cells _in vivo_, by parallel utilisation of objective image analysis and multiparameter laser flow microfluorimetry, both correlated


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Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS TEMPORAL AND SPATIAL TOPOGRAPHY OF CELL PROLIFERATION IN CANCER Article 15 March 2022 FLOW CYTOMETRIC SINGLE CELL-BASED ASSAY


TO SIMULTANEOUSLY DETECT CELL DEATH, CELL CYCLING, DNA CONTENT AND CELL SENESCENCE Article 09 March 2022 A MACHINE LEARNING APPROACH FOR SINGLE CELL INTERPHASE CELL CYCLE STAGING Article


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of Biophysics, Temple University Health Sciences Center, Philadelphia, 19140 C. A. NICOLINI, W. A. LINDEN, S. ZIETZ & C. T. WU Authors * C. A. NICOLINI View author publications You can


also search for this author inPubMed Google Scholar * W. A. LINDEN View author publications You can also search for this author inPubMed Google Scholar * S. ZIETZ View author publications


You can also search for this author inPubMed Google Scholar * C. T. WU View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints


and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE NICOLINI, C., LINDEN, W., ZIETZ, S. _et al._ Identification of non-proliferating cells in melanoma B16 tumour. _Nature_ 270, 607–609


(1977). https://doi.org/10.1038/270607a0 Download citation * Received: 07 June 1977 * Accepted: 17 October 1977 * Issue Date: 15 December 1977 * DOI: https://doi.org/10.1038/270607a0 SHARE


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