Lowering of hypertension by central saralasin in the absence of plasma renin

ABSTRACT A ROLE for the renin-angiotensin system in the development or maintenance of increased blood pressure of spontaneously hypertensive (SH) rats has not been substantiated. These

animals are considered the best model for human essential hypertension. Although there have been reports of unusually high concentrations of renin in the plasma of young SH rats2, their

pathophysiological relevance has been questioned3 and, as we report here, high blood pressure is maintained even after nephrectomy. But angiotensin from the brain isorenin–angiotensin system

(Iso–RAS) could be involved4,6. All the components of that system have been identified in brain tissue, including the enzyme iso-renin4–6, the substrate, angiotensinogen7, angiotensin I and

converting enzyme6,8 which hydrolyses angiotensin I to form the biologically active octapeptide angiotensin II. Angiotensin II is also present in brain tissue6. When it is injected

intraventricularly into the brain angiotensin II produces a prolonged increase in blood pressure9. Therefore, if angiotensin II concentrations are increased in the brains of SH rats they

could be involved in the hypertensive state independently of angiotensin levels from renal origin in plasma. Using the competitive antagonist Sar-1-Ala-8-angiotensin II (saralasin acetate,

P113, Norwich Pharmacal) in SH and nephrectomised SH rats, we have confirmed this possibility. Access through your institution Buy or subscribe This is a preview of subscription content,

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OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS ESAXERENONE: BLOOD PRESSURE REDUCTION AND

CARDIORENAL PROTECTION WITHOUT REFLEX SYMPATHETIC ACTIVATION IN SALT-LOADED STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS Article 27 May 2024 CLARIFICATION OF HYPERTENSION MECHANISMS PROVIDED

BY THE RESEARCH OF CENTRAL CIRCULATORY REGULATION Article 05 June 2023 CONTRIBUTION OF AFFERENT RENAL NERVE SIGNALS TO ACUTE AND CHRONIC BLOOD PRESSURE REGULATION IN STROKE-PRONE

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Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 6900, Heidelberg, FRG M. IAN

PHILLIPS, JOHANNES F. E. MANN, HIDEYUKI HAEBARA, WILLIAM E. HOFFMAN, RAINER DIETZ, PIERRE SCHELLING & DETLEV GANTEN Authors * M. IAN PHILLIPS View author publications You can also search

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ARTICLE PHILLIPS, M., MANN, J., HAEBARA, H. _et al._ Lowering of hypertension by central saralasin in the absence of plasma renin. _Nature_ 270, 445–447 (1977).

https://doi.org/10.1038/270445a0 Download citation * Received: 27 July 1977 * Accepted: 27 August 1977 * Issue Date: 01 December 1977 * DOI: https://doi.org/10.1038/270445a0 SHARE THIS

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