Study of membrane permeability changes by fluctuation analysis


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ABSTRACT The molecular basis of the changes in membrane permeability that underlie the nerve impulse can be studied by statistical analysis of the random fluctuations in current through the


nerve membrane. Such “noise analysis” has already begun to clarify the nature of the gating mechanisms that control the flow of ions across the membrane at the neuromuscular junction. Access


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SIMILAR CONTENT BEING VIEWED BY OTHERS AGING POWER SPECTRUM OF MEMBRANE PROTEIN TRANSPORT AND OTHER SUBORDINATED RANDOM WALKS Article Open access 25 October 2021 ESTIMATION OF CUMULATIVE


AMPLITUDE DISTRIBUTIONS OF MINIATURE POSTSYNAPTIC CURRENTS ALLOWS CHARACTERISING THEIR MULTIMODALITY, QUANTAL SIZE AND VARIABILITY Article Open access 20 September 2023 FLUORESCENCE


FLUCTUATION SPECTROSCOPY ENABLES QUANTIFICATION OF POTASSIUM CHANNEL SUBUNIT DYNAMICS AND STOICHIOMETRY Article Open access 21 May 2021 REFERENCES * Hodgkin, A. L., Huxley, A. F. & Katz,


B. _J. Physiol., Lond._ 116, 424–448 (1952). Article  CAS  Google Scholar  * Hodgkin, A. L. & Huxley, A. F. _J. Physiol., Lond._ 116, 449–472 (1952); _ibid._ 116, 473–496 (1952);


_ibid._ 116, 497–506 (1952); _ibid._ 117, 500–544 (1952). Article  CAS  Google Scholar  * Stevens, C. F. _Fedn. Proc._ 34, 1364–1369 (1975). CAS  Google Scholar  * Verveen, A. A. &


DeFelice, L. J. _Prog. Biophys. molec. Biol._ 28, 189–265 (1974). Article  CAS  Google Scholar  * Conti, F. & Wanke, E. _Q. Rev. Biophys._ 8, 451–506 (1975). Article  CAS  Google Scholar


  * Neher, E. & Stevens, C. F. _Ann. Rev. Biophys. Bioeng._, 6, 345–381 (1977). Article  CAS  Google Scholar  * Feller, W. _An Introduction to Probability Theory and Its Applications_ 2


(Wiley, New York, 1966). MATH  Google Scholar  * Moran, P. A. P. _An Introduction to Probability Theory_ (Clarendon, Oxford, 1968). MATH  Google Scholar  * Magleby, K. L. & Stevens, C.


F. _J. Physiol., Lond._ 223, 151–171 (1972); _ibid._ 223, 173–197 (1972). Article  CAS  Google Scholar  * Katz, B. & Miledi, R. _Nature_ 226, 962–963 (1970); 224, 665–699 (1972). Article


  ADS  CAS  Google Scholar  * Anderson, C. R. & Stevens, C. F. _J. Physiol., Lond._ 235, 655–691 (1973). Article  CAS  Google Scholar  * Neher, E. & Sakmann, B. _Nature_ 260, 779–802


(1976). Article  Google Scholar  * Colquhoun, D., Large, W. A. & Rang, H. P. _J. Physiol., Lond._ 266, 361–395 (1977). Article  CAS  Google Scholar  * Katz, B. & Miledi, R. _J.


Physiol., Lond._ 230, 707–717 (1973). Article  CAS  Google Scholar  * Ruff, R. L. _Biophys. J._ 16, 433–439 (1976); _J. Physiol._ 264, 89–124 (1977). Article  ADS  CAS  Google Scholar  *


Derksen, H. E. & Verveen, A. A. _Science_ 151, 1388–1389 (1966). Article  ADS  CAS  Google Scholar  * Verveen, A. A. _Fluctuation in Excitability_ 1–76 (Durkkerij Holland N. V.,


Amsterdam, 1961). Google Scholar  * Blair, E. A. & Erlanger, J. _Am. J. Physiol._ 106, 524–564 (1933). Google Scholar  * Pecher, C., _Arch. Internat. Physiol._ 49, 129–152 (1939). Google


Scholar  * Begenisich, T. & Stevens, C. F. _Biophys. J._ 15, 843–846 (1975). Article  ADS  CAS  Google Scholar  * Conti, F., Hille, B., Neumcke, B., Nonner, W. & Stämpfli, R. _J.


Physiol., Lond._ 262, 699–727 (1976); _ibid._ 262, 729–742 (1976). Article  CAS  Google Scholar  * Sigworth, F. J., _Nature_ 270, 265–267 (1977). Article  ADS  CAS  Google Scholar  *


Woodhull, A. M. _J. gen. Physiol._ 61, 687–708 (1973). Article  CAS  Google Scholar  * Siebenga, E., Meyer, A. W. A. & Verveen, A. A. _Pflügers Arch._ 341, 87–96 (1973). Article  CAS 


Google Scholar  * Fishman, H. M. _Proc. natn. Acad. Sci. U.S.A._ 70, 876–879 (1973). Article  ADS  CAS  Google Scholar  * Fishman, H. M., Moore, L. E. & Poussart, D. J. M. _J. membr.


Biol._ 24, 305–328 (1975). Article  CAS  Google Scholar  * Conti, F., DeFelice, L. J. & Wanke, E. _J. Physiol., Lond._ 248, 45–82 (1975). Article  CAS  Google Scholar  * Fishman, H. M.


_J. membr. Biol._ 24, 265–277 (1975). Article  CAS  Google Scholar  * van den Berg, R. J., de Goede, J. & Verveen, A. A. _Pflügers Arch._ 360, 17–23 (1975). Article  CAS  Google Scholar


  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06510 Charles F.


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CITE THIS ARTICLE Stevens, C. Study of membrane permeability changes by fluctuation analysis. _Nature_ 270, 391–396 (1977). https://doi.org/10.1038/270391a0 Download citation * Issue Date:


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