Antibodies to melanoma cell and bcg antigens in sera from tumour-free individuals and from melanoma patients

ABSTRACT THE _Mycobacterium bovis_ strain BCG shares antigenic components with several neoplasms, including human malignant melanoma1–5. Other species of bacteria also have antigenic

similarities with a guinea pig hepatoma6. Antibodies to mycobacteria and other bacterial antigens are universally present in sera from normal humans7,8. Since there is a broad range of

shared or cross-reactive antigens among mycobacteria and unrelated microorganisms9, it is conceivable that an immune response by normal humans to mycobacteria has been induced by exposure to

taxonomically unrelated microorganisms ubiquitous in the environment. Cytotoxic reactions by lymphoid cells from normal animals and humans to many kinds of tumour cells have been

reported10–15. Antibodies in sera from patients with various neoplasms have often been observed that react with antigens derived from their own tumours or from those of the same histological

type16–18.Humoral responses to tumour-associated antigens have also been noted in sera from normal humans, gibbons and mice19–21. We have investigated whether sera from normal, tumour-free

humans contain antibodies which can react with melanoma-associated as well as with BCG antigens. If this were the case, perhaps immunological reactions by normal humans to certain tumours

are widespread and reflect previous sensitisation by microorganisms. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution

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about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS IDENTIFICATION OF BACTERIA-DERIVED HLA-BOUND PEPTIDES IN MELANOMA Article

17 March 2021 MONOCLONAL ANTIBODIES FROM HUMANS WITH _MYCOBACTERIUM TUBERCULOSIS_ EXPOSURE OR LATENT INFECTION RECOGNIZE DISTINCT ARABINOMANNAN EPITOPES Article Open access 12 October 2021

TUMOR-ASSOCIATED AUTOANTIBODIES FROM MOUSE BREAST CANCER MODELS ARE FOUND IN SERUM OF BREAST CANCER PATIENTS Article Open access 11 May 2021 REFERENCES * Borsos, T., and Rapp, H. J., _J.

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AND AFFILIATIONS * National Jewish Hospital and Research Center, Denver, Colorado, 80206 P. MINDEN, C. JARRETT & J. K. MCCLATCHY * MD Anderson Hospital and Tumor Institute, Houston,

Texas, 77025 J. U. GUTTERMAN & E. M. HERSH Authors * P. MINDEN View author publications You can also search for this author inPubMed Google Scholar * C. JARRETT View author publications

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PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE MINDEN, P., JARRETT, C., MCCLATCHY, J. _et al._ Antibodies to melanoma cell and BCG antigens in sera from

tumour-free individuals and from melanoma patients. _Nature_ 263, 774–777 (1976). https://doi.org/10.1038/263774a0 Download citation * Received: 02 July 1976 * Accepted: 23 August 1976 *

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