Mechanisms of bone destruction in the development of skeletal metastases


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ABSTRACT SKELETAL metastases are associated with progressive bone destruction but the pathogenesis is not well understood. I report here experiments which indicate that two principal


mechanisms are involved. The first is mediated by osteoclasts and the tumour secretes a diffusable osteoclast activating factor; the second functions when the residual trabeculae are


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REFERENCES * Galasko, C. S. B., _Bone Jt Surg._, 57 -B, 353–359 (1975). Article  CAS  Google Scholar  * Galasko, C. S. B., and Bennett, A., _Nature_, 263, 508–510 (1976). Article  ADS  CAS 


Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Orthopaedic Unit, Royal Postgraduate Medical School, London, W12 OHS, UK C. S. B. GALASKO Authors * C. S. B.


GALASKO View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE GALASKO, C.


Mechanisms of bone destruction in the development of skeletal metastases. _Nature_ 263, 507–508 (1976). https://doi.org/10.1038/263507a0 Download citation * Received: 28 June 1976 *


Accepted: 25 August 1976 * Issue Date: 07 October 1976 * DOI: https://doi.org/10.1038/263507a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content:


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