Experimental allergic encephalomyelitis: dissociation of neurological symptoms from lipid alterations in brain

ABSTRACT EXPERIMENTAL allergic encephalomyelitis (EAE) is an autoimmune, paralytic disease that can be induced in experimental animals by injection of whole tissue from the central nervous

system (CNS), or the purified myelin basic protein (PBP) homogenised in Freund's adjuvant. In some respects, it resembles certain human demyelinating diseases1,2. Preferential changes

occur in the metabolism of glycosphingolipids in the CNS3–6, some of which do not seem to be directly related to the presence of clinical symptoms4. In the guinea pig, changes in some of the

myelin components seem to depend on the disease-inducing substance used. The cerebroside content of the CNS changes when this animal is sensitised with whole CNS, or with PBP and CNS

lipids, but not when PBP alone is used as encephalitogen. The content of sulphatides changes the extent depending on the composition of the encephalitogenic preparation injected6. We report

here that changes in the level of glycosphingolipids may arise in response to components other than the myelin basic protein and without the simultaneous occurrence of paralytic symptoms.

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support SIMILAR CONTENT BEING VIEWED BY OTHERS RECOMBINANT MYELIN OLIGODENDROCYTE GLYCOPROTEIN QUALITY MODIFIES EVOLUTION OF EXPERIMENTAL AUTOIMMUNE ENCEPHALITIS IN MACAQUES Article 10

August 2021 PROLONGED RESIDENCE OF AN ALBUMIN–IL-4 FUSION PROTEIN IN SECONDARY LYMPHOID ORGANS AMELIORATES EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS Article 12 October 2020 CD8+ T CELLS

SPECIFIC FOR CRYPTIC APOPTOSIS-ASSOCIATED EPITOPES EXACERBATE EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS Article Open access 29 October 2021 REFERENCES * Kies, M. W., Alvord, E. C., Jr,

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Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina BRUNO MAGGIO & FEDERICO A. CUMAR Authors * BRUNO MAGGIO View author publications You can also search for this author

inPubMed Google Scholar * FEDERICO A. CUMAR View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS

ARTICLE CITE THIS ARTICLE MAGGIO, B., CUMAR, F. Experimental allergic encephalomyelitis: dissociation of neurological symptoms from lipid alterations in brain. _Nature_ 253, 364–365 (1975).

https://doi.org/10.1038/253364a0 Download citation * Received: 09 September 1974 * Revised: 20 November 1974 * Issue Date: 31 January 1975 * DOI: https://doi.org/10.1038/253364a0 SHARE THIS

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