Uptake of the neurotransmitter candidate glutamate by glia

ABSTRACT GLUTAMIC acid is the primary candidate for a role as an excitatory transmitter at synapses mediating the primary afferent pathway and cortical pathways in mammals1. Seeking to gain

evidence for this, various laboratories have looked for a mechanism for the eflficient removal of glutamic acid from the synaptic cleft. Following the paradigm of monoamine synapses, in

which high affinity uptake systems apparently localised in the presynaptic membrane remove transmitter after its action at the postsynaptic membrane2, high affinity uptake systems for

glutamate removal have been sought. Logan and Snyder3 described a high affinity transport system for glutamate in a synaptosomal preparation, and postulated that it might serve to localise

glutamate-mediated synapses. Recent evidence has suggested that the transport systems involved in the removal of putative amino acid transmitters from the synaptic cleft are not localised

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FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS WIDESPREAD CO-RELEASE OF GLUTAMATE AND GABA THROUGHOUT THE MOUSE BRAIN Article Open access 13 November 2024

PHYSIOLOGICAL SYNAPTIC ACTIVITY AND RECOGNITION MEMORY REQUIRE ASTROGLIAL GLUTAMINE Article Open access 08 February 2022 SYMPORT AND ANTIPORT MECHANISMS OF HUMAN GLUTAMATE TRANSPORTERS

Article Open access 04 May 2023 REFERENCES * Hammerschlag, R., and Weinreich, D., in _Adv. Biochem. Psychopharmac_. (edit. by Costa, E., and Greengard P.), 6, 165–180 (Raven Press, New York,

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Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, 63110 FRITZ A. HENN * Department of

Anatomy, Washington University School of Medicine, St Louis, Missouri, 63110 MILTON N. GOLDSTEIN * Institute of Neurobiology, Götebory University School of Medicine, Göteborg, Sweden ANDERS

HAMBERGER Authors * FRITZ A. HENN View author publications You can also search for this author inPubMed Google Scholar * MILTON N. GOLDSTEIN View author publications You can also search for

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ABOUT THIS ARTICLE CITE THIS ARTICLE HENN, F., GOLDSTEIN, M. & HAMBERGER, A. Uptake of the neurotransmitter candidate glutamate by glia. _Nature_ 249, 663–664 (1974).

https://doi.org/10.1038/249663a0 Download citation * Received: 06 February 1974 * Issue Date: 14 June 1974 * DOI: https://doi.org/10.1038/249663a0 SHARE THIS ARTICLE Anyone you share the

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