G1 cell-cycle arrest and apoptosis by histone deacetylase inhibition in mll-af9 acute myeloid leukemia cells is p21 dependent and mll-af9 independent

Access through your institution Buy or subscribe Acute myeloid leukemia (AML) with MLL gene rearrangements (MLLmut) is often associated with M5 or M4 FAB subtypes, is frequent in infants and

in patients with secondary leukemia following treatment with DNA topoisomerase-II inhibitors.1 MLLmut are predictive of a poor clinical outcome in AML, even if the outcome of patients with

t(9;11) is more favorable than that with other MLLmut. The MLL gene (11q23) is involved in about 60 different translocations and about 30 partner genes have been identified. The most common

translocation in AML is t(9;11)(p22;q23) giving rise to MLL-AF9.1 The HDAC inhibitor (HDACi) valproic acid (VPA) induces tumor-selective apoptosis through activation of the death receptor

pathway AML with PML-RAR-alpha or AML1-ETO.2 This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal

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280: 24315–24321. Article  CAS  Google Scholar  Download references ACKNOWLEDGEMENTS This work was supported by grants from AIRC (to AP and regional grant), MURST/FISR, and by the University

of Bologna. RS, RF and MF were supported by AGEOP. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pediatrics, University of Bologna, Bologna, Italy R Tonelli, R Sartini, R

Fronza, F Freccero, M Franzoni & A Pession * Department of Physics, University of Bologna, Bologna, Italy D Dongiovanni & R Campanini * Department of Experimental Oncology, European

Institute of Oncology, Milan, Italy M Ballarini & S Minucci * Division of Medical Genetics, S. Orsola Hospital, Bologna, Italy S Ferrari * Servizio di Genetica Medica, IRCCS-Ospedale

CSS, San Giovanni Rotondo, Italy M D'apolito * Biotech Biotechnologies Laboratory s.r.l., Parma, Italy G Di Cola * Department of Biochemistry, University of Bologna, Bologna, Italy G

Capranico & A Khobta * Department of Pediatrics, University of Modena, Modena, Italy P Paolucci * Department of Biomolecular Sciences and Biotechnology, University of Milan, Milan, Italy

S Minucci Authors * R Tonelli View author publications You can also search for this author inPubMed Google Scholar * R Sartini View author publications You can also search for this author

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You can also search for this author inPubMed Google Scholar * G Capranico View author publications You can also search for this author inPubMed Google Scholar * A Khobta View author

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View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to A Pession. ADDITIONAL INFORMATION Supplementary Information

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SUPPLEMENTARY INFORMATION (XLS 187 KB) SUPPLEMENTARY MATERIAL (DOC 982 KB) RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Tonelli, R., Sartini, R.,

Fronza, R. _et al._ G1 cell-cycle arrest and apoptosis by histone deacetylase inhibition in MLL-AF9 acute myeloid leukemia cells is p21 dependent and MLL-AF9 independent. _Leukemia_ 20,

1307–1310 (2006). https://doi.org/10.1038/sj.leu.2404221 Download citation * Published: 13 April 2006 * Issue Date: 01 July 2006 * DOI: https://doi.org/10.1038/sj.leu.2404221 SHARE THIS

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