Antigen binding cells in tolerant animals

ABSTRACT THE immune response involves the appearance of anti-body secreting cells as well as antigen binding cells. Antibody secreting cells can be counted _in vitro_ using-Jerne and

Nordin's local haemolysis in gel (LHG) assay1, and are then called plaque forming cells (PFC). Antigen binding cells can be recognized by their ability to bind particulate antigens such

as sheep red cells (SRB) to their surfaces and have been named rosette forming cells (RFC)2,3. It is likely that RFC represent a mixture of antibody secreting cells and non-antibody

secreting cells. Howard _et al._4 studied the RFC response in the spleens of mice tolerant to pneumococcal polysaccharide. Although serum antibodies could not be seen in these animals a

considerable number, larger, in fact, in “tolerant” than in optimally immunized animals, of RFC was found. They explained these findings on the basis that antibody secreting cells existed

but that the humoral antibodies produced were neutralized extra-cellularly by persisting undegraded antigen. Access through your institution Buy or subscribe This is a preview of

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15 January 2021 MODELING HUMAN ADAPTIVE IMMUNE RESPONSES WITH TONSIL ORGANOIDS Article 11 January 2021 REFERENCES * Jerne, N. K., and Nordin, A. A., _Science_, 140, 405 (1963). Article  ADS

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INFORMATION AUTHORS AND AFFILIATIONS * Department of Bacteriology, Karolinska Institutet Medical School, S–104 01, Stockholm, 60 OLOF SJÖBERG & ERNA MÖLLER Authors * OLOF SJÖBERG View

author publications You can also search for this author inPubMed Google Scholar * ERNA MÖLLER View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND

PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE SJÖBERG, O., MÖLLER, E. Antigen Binding Cells in Tolerant Animals. _Nature_ 228, 780–781 (1970).

https://doi.org/10.1038/228780a0 Download citation * Received: 31 March 1970 * Revised: 22 June 1970 * Issue Date: 21 November 1970 * DOI: https://doi.org/10.1038/228780a0 SHARE THIS ARTICLE

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