Protection of rabbits against experimental rabies by poly i·poly c

ABSTRACT THERE has been great interest in the possible use of interferon in the prophylaxis of rabies1,2, but interferon administered to mice failed to protect them from experimental

infection, with the CVS strain of rabies, possibly because the amount injected may have been insufficient to be effective in the cells of the central nervous system3. On the other hand, the

preinjection of rabbits with either neuro-vaccinia virus or virus-free extracts of tissues from infected animals was partially protective against challenge with rabies street virus,

presumably as a result of interferon production4. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS

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institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS EFFECTS OF ADJUVANTS IN A RABIES-VECTORED EBOLA VIRUS VACCINE ON PROTECTION FROM

SURROGATE CHALLENGE Article Open access 08 February 2023 SITES RESPONSIBLE FOR INFECTIVITY AND ANTIGENICITY ON NERVOUS NECROSIS VIRUS (NNV) APPEAR TO BE DISTINCT Article Open access 11

February 2021 RABIES VIRUS LARGE PROTEIN-DERIVED T-CELL IMMUNOGEN FACILITATES RAPID VIRAL CLEARANCE AND ENHANCES PROTECTION AGAINST LETHAL CHALLENGE IN MICE Article Open access 18 April 2025

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Article  ADS  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Connaught Medical Research Laboratories, University of Toronto, Toronto PAUL FENJE *

Department of Epidemiology and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, 15213 BOSKO POSTIC Authors * PAUL FENJE View author

publications You can also search for this author inPubMed Google Scholar * BOSKO POSTIC View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND

PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE FENJE, P., POSTIC, B. Protection of Rabbits against Experimental Rabies by Poly I·poly C. _Nature_ 226, 171–172

(1970). https://doi.org/10.1038/226171a0 Download citation * Received: 20 October 1969 * Issue Date: 11 April 1970 * DOI: https://doi.org/10.1038/226171a0 SHARE THIS ARTICLE Anyone you share

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