Role of lysosomes in amelogenesis

ABSTRACT PREVIOUS studies in amelogenesis have shown that the organic matrix of enamel undergoes marked changes during development. These include a loss of protein and a change in the

amino-acid composition1–3. Experiments with labelled protein precursors show that label first appears in a discrete layer in the enamel but soon spreads throughout the matrix4,5. Only

tentative explanations for such processes have so far been put forward2,3. More recently, however, preliminary histochemical studies have shown that several enzymes belonging to the

lysosomal system are present in ameloblasts6. Lysosomes are known to participate in both intra and extracellular degradative processes7, and it is possible that lysosomal enzymes may be the

agents responsible for some of the changes observed in enamel matrix during development. We have investigated this possibility using the more powerful technique of enzyme cytochemistry

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FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS MMP20-GENERATED AMELOGENIN CLEAVAGE PRODUCTS PREVENT FORMATION OF FAN-SHAPED ENAMEL MALFORMATIONS Article Open access

19 May 2021 WDR72 REGULATES VESICLE TRAFFICKING IN AMELOBLASTS Article Open access 18 February 2022 CHEMICAL GRADIENTS IN HUMAN ENAMEL CRYSTALLITES Article 01 July 2020 REFERENCES *

Glimcher, M. J., Levine, P. T., and Bonar, L. C., _J. Ultrastruct. Res._, 13, 281 (1965). Article  CAS  Google Scholar  * Eastoe, J. E., _Brit. Dent. J._, 121, 451 (1966). CAS  PubMed 

Google Scholar  * Stack, M. V., _Odont. Rev._, 17, 101 (1967). Google Scholar  * Young, R. W., and Greulich, R. C., _Arch. Oral Biol._, 8, 509 (1963). Article  CAS  Google Scholar  *

Greulich, R. C., and Slavkin, H. C., in _The Use of Radioautography in Investigating Protein Synthesis_ (edit. by C. P. Leblond and K. B. Warren), 199 (Academic Press, New York, 1965). Book

  Google Scholar  * Katchburian, E., Katchburian, A. V., and Pearse, A. G. E., _J. Anat._, 101, 783 (1967). CAS  PubMed  PubMed Central  Google Scholar  * De Duve, C., and Wattiaux, R.,

_Ann. Rev. Physiol._, 28, 435 (1966). Article  CAS  Google Scholar  * Karnovsky, M. J., _J. Cell Biol._, 27, 137A (1965). Google Scholar  * Novikoff, A. B., Albala, A., and Biempica, L., _J.

Histochem. Cytochem._, 16, 299 (1968). Article  CAS  Google Scholar  * Reith, E. J., _J. Ultrastruct. Res._, 17, 503 (1967). Article  ADS  CAS  Google Scholar  * Katchburian, E., thesis,

University of London (1968). * Warshawsky, H., _Anat. Rec._, 161, 211 (1968). Article  CAS  Google Scholar  * Garant, P. R., and Nalbandian, J., _J. Ultrastruct. Res._, 23, 427 (1968).

Article  CAS  Google Scholar  * Dingle, J. T., Fell, H. B., and Glauert, A. M., _J. Cell Sci._, 4, 139 (1969). CAS  PubMed  Google Scholar  * Vaes, G., _Bruxelles Médical_, 46, 1133 (1966).

CAS  PubMed  Google Scholar  * Smith, R. E., and Farquhar, M. G., _J. Cell Biol._, 31, 319 (1966). Article  CAS  Google Scholar  * De Duve, C., in _Injury, Inflammation and Immunity_, 283

(Williams and Wilkins, 1964). Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Cytochemistry, Courtauld Institute of Biochemistry, The

Middlesex Hospital Medical School, London, W1 E. KATCHBURIAN & S. J. HOLT Authors * E. KATCHBURIAN View author publications You can also search for this author inPubMed Google Scholar *

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KATCHBURIAN, E., HOLT, S. Role of Lysosomes in Amelogenesis. _Nature_ 223, 1367–1368 (1969). https://doi.org/10.1038/2231367a0 Download citation * Received: 11 July 1969 * Issue Date: 27

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