Role of lysosomes in amelogenesis


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ABSTRACT PREVIOUS studies in amelogenesis have shown that the organic matrix of enamel undergoes marked changes during development. These include a loss of protein and a change in the


amino-acid composition1–3. Experiments with labelled protein precursors show that label first appears in a discrete layer in the enamel but soon spreads throughout the matrix4,5. Only


tentative explanations for such processes have so far been put forward2,3. More recently, however, preliminary histochemical studies have shown that several enzymes belonging to the


lysosomal system are present in ameloblasts6. Lysosomes are known to participate in both intra and extracellular degradative processes7, and it is possible that lysosomal enzymes may be the


agents responsible for some of the changes observed in enamel matrix during development. We have investigated this possibility using the more powerful technique of enzyme cytochemistry


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FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS MMP20-GENERATED AMELOGENIN CLEAVAGE PRODUCTS PREVENT FORMATION OF FAN-SHAPED ENAMEL MALFORMATIONS Article Open access


19 May 2021 WDR72 REGULATES VESICLE TRAFFICKING IN AMELOBLASTS Article Open access 18 February 2022 CHEMICAL GRADIENTS IN HUMAN ENAMEL CRYSTALLITES Article 01 July 2020 REFERENCES *


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(Williams and Wilkins, 1964). Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Cytochemistry, Courtauld Institute of Biochemistry, The


Middlesex Hospital Medical School, London, W1 E. KATCHBURIAN & S. J. HOLT Authors * E. KATCHBURIAN View author publications You can also search for this author inPubMed Google Scholar *


S. J. HOLT View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE


KATCHBURIAN, E., HOLT, S. Role of Lysosomes in Amelogenesis. _Nature_ 223, 1367–1368 (1969). https://doi.org/10.1038/2231367a0 Download citation * Received: 11 July 1969 * Issue Date: 27


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