- Select a language for the TTS:
- UK English Female
- UK English Male
- US English Female
- US English Male
- Australian Female
- Australian Male
- Language selected: (auto detect) - EN
Play all audios:
ABSTRACT PREVIOUS studies in amelogenesis have shown that the organic matrix of enamel undergoes marked changes during development. These include a loss of protein and a change in the
amino-acid composition1–3. Experiments with labelled protein precursors show that label first appears in a discrete layer in the enamel but soon spreads throughout the matrix4,5. Only
tentative explanations for such processes have so far been put forward2,3. More recently, however, preliminary histochemical studies have shown that several enzymes belonging to the
lysosomal system are present in ameloblasts6. Lysosomes are known to participate in both intra and extracellular degradative processes7, and it is possible that lysosomal enzymes may be the
agents responsible for some of the changes observed in enamel matrix during development. We have investigated this possibility using the more powerful technique of enzyme cytochemistry
combined with electron microscopy. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your
institution Subscribe to this journal Receive 51 print issues and online access $199.00 per year only $3.90 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access
to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our
FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS MMP20-GENERATED AMELOGENIN CLEAVAGE PRODUCTS PREVENT FORMATION OF FAN-SHAPED ENAMEL MALFORMATIONS Article Open access
19 May 2021 WDR72 REGULATES VESICLE TRAFFICKING IN AMELOBLASTS Article Open access 18 February 2022 CHEMICAL GRADIENTS IN HUMAN ENAMEL CRYSTALLITES Article 01 July 2020 REFERENCES *
Glimcher, M. J., Levine, P. T., and Bonar, L. C., _J. Ultrastruct. Res._, 13, 281 (1965). Article CAS Google Scholar * Eastoe, J. E., _Brit. Dent. J._, 121, 451 (1966). CAS PubMed
Google Scholar * Stack, M. V., _Odont. Rev._, 17, 101 (1967). Google Scholar * Young, R. W., and Greulich, R. C., _Arch. Oral Biol._, 8, 509 (1963). Article CAS Google Scholar *
Greulich, R. C., and Slavkin, H. C., in _The Use of Radioautography in Investigating Protein Synthesis_ (edit. by C. P. Leblond and K. B. Warren), 199 (Academic Press, New York, 1965). Book
Google Scholar * Katchburian, E., Katchburian, A. V., and Pearse, A. G. E., _J. Anat._, 101, 783 (1967). CAS PubMed PubMed Central Google Scholar * De Duve, C., and Wattiaux, R.,
_Ann. Rev. Physiol._, 28, 435 (1966). Article CAS Google Scholar * Karnovsky, M. J., _J. Cell Biol._, 27, 137A (1965). Google Scholar * Novikoff, A. B., Albala, A., and Biempica, L., _J.
Histochem. Cytochem._, 16, 299 (1968). Article CAS Google Scholar * Reith, E. J., _J. Ultrastruct. Res._, 17, 503 (1967). Article ADS CAS Google Scholar * Katchburian, E., thesis,
University of London (1968). * Warshawsky, H., _Anat. Rec._, 161, 211 (1968). Article CAS Google Scholar * Garant, P. R., and Nalbandian, J., _J. Ultrastruct. Res._, 23, 427 (1968).
Article CAS Google Scholar * Dingle, J. T., Fell, H. B., and Glauert, A. M., _J. Cell Sci._, 4, 139 (1969). CAS PubMed Google Scholar * Vaes, G., _Bruxelles Médical_, 46, 1133 (1966).
CAS PubMed Google Scholar * Smith, R. E., and Farquhar, M. G., _J. Cell Biol._, 31, 319 (1966). Article CAS Google Scholar * De Duve, C., in _Injury, Inflammation and Immunity_, 283
(Williams and Wilkins, 1964). Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Cytochemistry, Courtauld Institute of Biochemistry, The
Middlesex Hospital Medical School, London, W1 E. KATCHBURIAN & S. J. HOLT Authors * E. KATCHBURIAN View author publications You can also search for this author inPubMed Google Scholar *
S. J. HOLT View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE
KATCHBURIAN, E., HOLT, S. Role of Lysosomes in Amelogenesis. _Nature_ 223, 1367–1368 (1969). https://doi.org/10.1038/2231367a0 Download citation * Received: 11 July 1969 * Issue Date: 27
September 1969 * DOI: https://doi.org/10.1038/2231367a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable
link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative