Cardiovascular effects of ah. 3365 (salbutamol)


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ABSTRACT THE β-adrenergic stimulant α-[(_t_-butylamino)methyl]-4-hydroxy-_m_-xylene-α1, α3-diol (salbutamol) acts selectively on bronchial muscle1. Studies with guinea-pig tissue have shown


that although it is as active as isoprenaline on bronchial muscle, it is 2,000 times less active on the isolated atria. Clinical studies have shown it to be an effective bronchodilator2, and


we now present evidence that its cardiovascular effects in man are negligible compared with those of isoprenaline. Access through your institution Buy or subscribe This is a preview of


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REFERENCES * Brittain, R. T., Farmer, J. B., Jack, D., Martin, L. E., and Simpson, W. T., _Nature_, 219, 862 (1968). Article  CAS  ADS  Google Scholar  * Palmer, K. N. V., and Diament, M.


L., _Brit. Med. J._, i, 31 (1969). * Kinsman, J. M., Moore, J. W., and Hamilton, W. F., _Amer. J. Physiol._, 89, 322 (1929). Article  Google Scholar  * Meier, P., and Zierler, K. L., _J.


Appl. Physiol._, 6, 731 (1954). Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Departments of Physiology and Medicine, University of


Aberdeen, G. R. KELMAN, K. N. V. PALMER & M. R. CROSS Authors * G. R. KELMAN View author publications You can also search for this author inPubMed Google Scholar * K. N. V. PALMER View


author publications You can also search for this author inPubMed Google Scholar * M. R. CROSS View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND


PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE KELMAN, G., PALMER, K. & CROSS, M. Cardiovascular Effects of AH.3365 (Salbutamol). _Nature_ 221, 1251 (1969).


https://doi.org/10.1038/2211251a0 Download citation * Received: 11 November 1968 * Revised: 22 January 1969 * Published: 01 March 1969 * Issue Date: 29 March 1969 * DOI:


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