Inactivation of isoniazid in burmese subjects

ABSTRACT INACTIVATION by acetylation of the anti-tuberculosis drug isoniazid _in vivo_ is subject to genetic polymorphism1–3. Studies of the gene frequency for rapid inactivation in

different regions have revealed considerable racial variations4–7. Because of the association of isoniazid neuropathy with slow inactivation of the drug in therapeutic practice8,9, the

recording of gene frequencies among different races and in different countries is of practical importance. It is also of ethnological value in studies of population migrations. This

communication reports such an investigation among Burmese subjects. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution

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about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS DRUG-RESISTANT TUBERCULOSIS: A PERSISTENT GLOBAL HEALTH CONCERN Article 22

March 2024 CORRELATION OF N-ACETYLTRANSFERASE 2 GENOTYPE AND ACETYLATION STATUS WITH PLASMA ISONIAZID CONCENTRATION AND ITS METABOLIC RATIO IN ETHIOPIAN TUBERCULOSIS PATIENTS Article Open

access 15 July 2023 PRISONS AS ECOLOGICAL DRIVERS OF FITNESS-COMPENSATED MULTIDRUG-RESISTANT _MYCOBACTERIUM TUBERCULOSIS_ Article 24 May 2021 REFERENCES * Knight, R. A., Selin, M. J., and

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Scholar  * Mitchison, D. A., in _Drugs, Parasites and Hosts_ (edit. by Goodwin, L. G. and Nimmo-Smith, R. H.), 267 (Churchill, London, 1962). Google Scholar  * Maher, J. R., Whitney, J. M.,

Chambers, J. S., and Stanonis, D. J., _Amer. Rev. Tuberc. Pulm. Dis._, 76, 852 (1957). CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of

Pharmacology and Therapeutics, St. Thomas's Hospital Medical School, London S. E. SMITH * Department of Pharmacology, Institute of Medicine I, Rangoon, Burma TUN KYI Authors * S. E.

SMITH View author publications You can also search for this author inPubMed Google Scholar * TUN KYI View author publications You can also search for this author inPubMed Google Scholar

RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE SMITH, S., KYI, T. Inactivation of Isoniazid in Burmese Subjects. _Nature_ 217, 1273 (1968).

https://doi.org/10.1038/2171273a0 Download citation * Received: 01 March 1968 * Issue Date: 30 March 1968 * DOI: https://doi.org/10.1038/2171273a0 SHARE THIS ARTICLE Anyone you share the

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