Effects of very large doses of penicillin g given orally to rats


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ABSTRACT Nimni and Bavetta1 reported a connective tissue disorder in rats fed penicillamine. The disorder was reflected by decreased breaking strength of unwounded and wounded skin,


decreased collagen synthesis in polyvinyl sponge implants and a diminished proportion of insoluble to soluble collagen in such granulomas. We have studied this phenomenon in rats and


guinea-pigs2–4 and have likened it to the lathyritic state induced by feeding β-amino propionitrile, a view also expressed by Nimni5. Penicillamine can be derived6 from both the _in vitro_


and the _in vivo_ hydrolysis of penicillin, so we set out to determine whether the feeding of very large doses of penicillin would cause a collagen defect similar to that caused by


penicillamine. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution


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ACCOMPANIED BY LESS SCARRING AFTER WOUNDING ON THE ABDOMINAL WALL IN MICE Article Open access 21 September 2021 REFERENCES * Nimni, M., and Bavetta, L., _Science_, 150, 905 (1965). Article 


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6, No. 7, 246 (Jan. 1966). Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Surgery and Department of Biochemistry, Albert Einstein College of


Medicine, Bronx, New York E. SEIFTER, J. J. MORRIS & S. M. LEVENSON Authors * E. SEIFTER View author publications You can also search for this author inPubMed Google Scholar * J. J.


MORRIS View author publications You can also search for this author inPubMed Google Scholar * S. M. LEVENSON View author publications You can also search for this author inPubMed Google


Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE SEIFTER, E., MORRIS, J. & LEVENSON, S. Effects of Very Large Doses of Penicillin _G_ given


Orally to Rats. _Nature_ 217, 1055–1056 (1968). https://doi.org/10.1038/2171055a0 Download citation * Received: 13 November 1967 * Revised: 31 January 1968 * Issue Date: 16 March 1968 * DOI:


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