Erythropoietin and the development of erythrocytes: effect of erythropoietin in vitro which simulates that of a massive dose in vivo

ABSTRACT During the differentiation of erythrocytes some cells develop which contain a high concentration of haemoglobin and no cytoplasmic basophilia. Erythropoietin has the effect of

increasing the proportion of these cells in preparations of marrow. Two of the communications which follow discuss the effect on these cells of erythropoietin and of ageing and haemorrhage.

The third communication describes a factor in the serum of a polycythaemic calf which enhances the activity of erythropoietin. Access through your institution Buy or subscribe This is a

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RAPID CYCLING AND LARGER RED CELLS DURING MOUSE AND HUMAN ERYTHROPOIESIS Article Open access 17 December 2021 ERYTHROPOIESIS: INSIGHTS FROM A GENOMIC PERSPECTIVE Article Open access 01

October 2024 A NEW ROLE FOR ERYTHROPOIETIN IN THE HOMEOSTASIS OF RED BLOOD CELLS Article Open access 08 January 2024 REFERENCES * Reissmann, K. R., and Ito, K., _Blood_, 28, 201 (1966). CAS

  PubMed  Google Scholar  * Gallagher, N. I., and Lange, R. D., _Proc. Soc. Exp. Biol. and Med._, 110, 422 (1962). Gallagher, N. I., Seifert, G. L., Callinan, J. L., Maes, A. A., and Lange,

R. D., _J. Lab. Clin. Med._, 61, 258 (1963). Article  Google Scholar  * Borsook, H., _Biol. Rev._, 41, 259 (1966). Article  CAS  Google Scholar  * Borsook, H., Teigler, D., and Gunderson,

A., _Arch. Biochem. Biophys._ (in the press). * Borsook, H., _Ann. NY Acad. Sci._ (in the press). * Lajtha, L. G., and Oliver, R., in _Ciba Foundation Symposium on Haemopoiesis_, 289

(Churchill, London, 1960). Stohlman, F., Howard, D., and Beland, A., _Proc. Soc. Exp. Biol. and Med._, 113, 986 (1963). Google Scholar  * Erslev, A. J., _Blood_, 14, 386 (1959). Alpen, E.

L., and Cranmore, D., in _The Kinetics of Cellular Proliferation_, 290 (Grune and Stratton, NY, 1959). Filmanowicz, E., and Gurney, C. W., _J. Lab. Clin. Med._, 57, 65 (1961). Google Scholar

  Download references AUTHOR INFORMATION Author notes * DIAN TEIGLER Present address: Department of Botany, University of Texas, Austin, Texas AUTHORS AND AFFILIATIONS * Space Sciences

Laboratory, University of California, Berkeley HENRY BORSOOK, KAREN RATNER, BRENDA TATTRIE & DIAN TEIGLER * Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester

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permissions ABOUT THIS ARTICLE CITE THIS ARTICLE BORSOOK, H., RATNER, K., TATTRIE, B. _et al._ Erythropoietin and the Development of Erythrocytes: Effect of Erythropoietin _in vitro_ which

simulates that of a Massive Dose _in vivo_. _Nature_ 217, 1024–1026 (1968). https://doi.org/10.1038/2171024a0 Download citation * Received: 23 January 1968 * Issue Date: 16 March 1968 * DOI:

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