Induction of histamine forming capacity in canine liver by endotoxin

ABSTRACT IT has been reported from this laboratory that the extreme susceptibility of adrenalectomized dogs to endotoxin is mainly a result of the development of an endogenous factor which

produces marked hepatic engorgement of the shocked animals1,2. This factor seemed to be formed in the liver when its glycogen becomes depleted in the absence of glucocorticoids. The

appearance of this factor in the circulating blood could be detected by injecting the shock serum into a normal recipient dog under pentobarbitone sodium anaesthesia when a delayed depressor

response caused by induction of hepatic engorgement could be observed. This “shock-factor” in the serum was found to be non-dialysable, heat-unstable (inactivated by heating at 56° C for 30

min) and contained in the serum protein fraction precipitable by 20 per cent to 34 per cent saturation with ammonium sulphate. Further experiments, shortly to be published, showed that

there was no appreciable release of histamine from the liver of endotoxin-shocked adrenalectomized dogs and that the “shock-factor” does not act as a histamine-releaser. The “shock-factor”

and the hepatic engorgement were examined, therefore, in relation to an induction of histamine formation in the liver. Dogs are known to have no detectable histamine forming capacity in

their tissues3, and so the possibility that histamine forming activity was induced in the liver of endotoxin-shocked adrenalectomized dogs was therefore examined, using the method of Waton3

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FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS ANGIOTENSIN-(1–7) TREATMENT BLOCKS LIPOPOLYSACCHARIDE-INDUCED ORGAN DAMAGE, PLATELET DYSFUNCTION, AND IL-6 AND NITRIC

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TRAUMA Article Open access 13 October 2021 SYMPATHETIC NERVES CONTROL BACTERIAL CLEARANCE Article Open access 14 September 2020 REFERENCES * Fukuda, T., Kobayashi, T., and Okada, M.,

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104, 379 (1960). Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Physiology, Chiba University School of Medicine, Japan TOKURO

FUKUDA Authors * TOKURO FUKUDA View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE

THIS ARTICLE FUKUDA, T. Induction of Histamine Forming Capacity in Canine Liver by Endotoxin. _Nature_ 214, 107–108 (1967). https://doi.org/10.1038/214107a0 Download citation * Issue Date:

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