A high relative biological efficiency of 650-kev neutrons and 250-kvp x-rays in somatic mutation induction

ABSTRACT THE mean linear energy transfers of 650-keV neutrons and of 250-kVp X-rays are so markedly different that it is not usually possible to establish a unique value for their relative

biological efficiency. For example, it is well known that the densely ionizing neutrons induce linear dose-response relationships for chromosome aberrations, whereas the dose-response curves

for X-rays are often non-linear. Moreover, the former radiation but not the latter is almost independent of environmental factors such as oxygen tension during irradiation. Under certain

conditions, and with certain biological test systems, however, some of these difficulties are minimized. For example, Neary _et al._1 compared the relative biological efficiency, in terms of

chromosome aberration induction, of 0.7- and 3.0-MeV neutrons with cobalt-60 γ-rays administered at low dose rates. There the dose-response relationships were almost linear, and relative

biological efficiency values of 35 were obtained; they also derived ultimate maximum relative biological efficiency values from a comparison of the one-hit components of the neutron and

γ-dose-response curves and found that these could be as high as 100. Similarly, Smith _et al._2, using a test system (somatic mutation induction in dry seed) in which the dose-response

relationship for X-rays was linear, obtained an average relative biological efficiency value of about 75 for mono-energetic neutrons of 0.43–1.80 MeV. Access through your institution Buy or

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EXPOSURES Article Open access 02 July 2020 REFERENCES * Neary, G. J., Savage, J. R. K., Evans, H. J., and Whittle, J., _Intern. J. Radiation Biol._, 6, 127 (1963). CAS  Google Scholar  *

Smith, H. H., Bateman, J. L., Quastler, H., and Rossi, H. H., _I. A. E. A. Symp. Biological Effects of Neutron Irradiation_ (in the press). * Davies, D. R., Sparrow, A. H., Woodley, R. G.,

and Maschke, A., _Nature_, 200, 277 (1963). Article  ADS  CAS  Google Scholar  * Rossi, H. H., Bateman, J. L., Bond, V. P., Goodman, L. J., and Stickley, E. E., _Rad. Res._, 13, 503 (1960).

Article  CAS  Google Scholar  * Conger, A. D., and Giles, jun., N. H., _Genetics_, 35, 397 (1950). CAS  PubMed  PubMed Central  Google Scholar  * _Nat. Bur. Stand. U.S. Handbook_, No. 63

(1957). * Bateman, J. B. (unpublished results). * Rossi, H. H. (unpublished results). * Cormack, D. Z., and Johns, H. E., _Brit. J. Radiol._, 25, 369 (1952). Article  CAS  Google Scholar  *

Boag, J. W., _Nat. Bur. Stand. U.S. Rep._ No. 2946 (1953). Download references AUTHOR INFORMATION Author notes * D. R. DAVIES Present address: Wantage Research Laboratory, Wantage, Berks

AUTHORS AND AFFILIATIONS * Biology Department, Brookhaven National Laboratory, Upton, New York D. R. DAVIES * Medical Department, Brookhaven National Laboratory, Upton, New York J. L.

BATEMAN Authors * D. R. DAVIES View author publications You can also search for this author inPubMed Google Scholar * J. L. BATEMAN View author publications You can also search for this

author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE DAVIES, D., BATEMAN, J. A High Relative Biological Efficiency of 650-keV

Neutrons and 250-kVp X-rays in Somatic Mutation Induction. _Nature_ 200, 485–486 (1963). https://doi.org/10.1038/200485a0 Download citation * Issue Date: 02 November 1963 * DOI:

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