Increased iron absorption without increase in the rate of erythropoiesis

ABSTRACT IT is generally agreed that under normal conditions in man the total body iron is maintained at a relatively constant level by some mechanism which regulates the amount of iron

absorbed from the gastro-intestinal tract. Apart from manipulating intra-luminal conditions within the intestine, numerous experimental conditions are known which increase iron absorption

and which have in common an accelerated erythropoietic rate. These include anoxic hypoxia1, cobalt administration2, erythropoietin administration (Mendel, G. A., unpublished observations),

pyridoxine deficiency3, acetyl phenylhydrazine induced hæmolytic anæmia4 and anæmia induced by loss of blood5. The rate of erythropoiesis has been considered of major importance under

‘physiological’ conditions in regulating iron absorption6,7. In certain disease states, such as hæmochromatosis, however, iron absorption may be increased without measurable increase in

erythropoietic rate8. It is the purpose of this preliminary communication to report an experimental condition in which gastro-intestinal iron absorption is increased above normal in the

virtual absence of erythropoiesis. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your

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FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS IRON FROM NANOSTRUCTURED FERRIC PHOSPHATE: ABSORPTION AND BIODISTRIBUTION IN MICE AND BIOAVAILABILITY IN IRON

DEFICIENT ANEMIC WOMEN Article Open access 18 February 2022 MECHANISMS CONTROLLING CELLULAR AND SYSTEMIC IRON HOMEOSTASIS Article 02 October 2023 SERUM ERYTHROFERRONE LEVELS DURING THE FIRST

MONTH OF LIFE IN PREMATURE INFANTS Article 10 August 2021 REFERENCES * Vassar, P. S., and Taylor, D. M., _Proc. Soc. Exp. Biol. and Med._, 93, 504 (1956). Article  CAS  Google Scholar  *

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Hospital*, 950 East 59th Street, Chicago, 37 GERALD A. MENDEL Authors * GERALD A. MENDEL View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND

PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE MENDEL, G. Increased Iron Absorption without Increase in the Rate of Erythropoiesis. _Nature_ 192, 878–879 (1961).

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