Thermal decarboxylation of some keto-acid hydrazones


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ABSTRACT THE 2,4-dinitrophenylhydrazones of keto-acids are frequently used to identify these metabolic intermediates. The clear statement by Clift and Cook1 regarding the ready thermal


decarboxylation of the 2,4-dinitrophenylhydrazones of oxaloacetic and acetoacetic acids has sometimes been overlooked, particularly in the use of melting points as a means of identification.


Some of our observations bear on the problem. SIMILAR CONTENT BEING VIEWED BY OTHERS A WAY TO THIOACETATE ESTERS COMPATIBLE WITH NON-OXIDATIVE PREBIOTIC CONDITIONS Article Open access 02


September 2020 PREBIOTIC FORMATION OF THIOESTERS VIA CYCLIC ANHYDRIDES AS A KEY STEP IN THE EMERGENCE OF METABOLISM Article Open access 27 February 2025 FORMATION OF THIOESTERS BY


DEHYDROGENATIVE COUPLING OF THIOLS AND ALCOHOLS WITH H2 EVOLUTION Article 28 September 2020 ARTICLE PDF REFERENCES * Clift, F. P., and Cook, R. P., _Biochem. J._, 26, 1800 (1932). Article 


CAS  Google Scholar  * Moriwaki, T., Katsuki, H., and Tanaka, S., _J. Chem. Soc. Japan_, 76, 1367 (1955). CAS  Google Scholar  * Metzler, D. E., Olivard, J., and Snell, E. E., _J. Amer.


Chem. Soc._, 76, 644 (1954). Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Division of Chemistry and Biochemistry, Institutum Divi Thomae,


Cincinnati, Ohio AMBROSE M. TOKUSHIGE & ELTON S. COOK Authors * AMBROSE M. TOKUSHIGE View author publications You can also search for this author inPubMed Google Scholar * ELTON S. COOK


View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE TOKUSHIGE, A., COOK,


E. Thermal Decarboxylation of Some Keto-Acid Hydrazones. _Nature_ 184, 267 (1959). https://doi.org/10.1038/184267a0 Download citation * Issue Date: 25 July 1959 * DOI:


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