High molecular weight ribonucleic acids from the nuclei of calf thymus


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ABSTRACT A RIBONUCLEIC acid fraction, which gives the characteristic sedimentation pattern shown in Fig. 1, has been isolated very recently from tobacco leaves1, mouse brain2 and microsomes


of rat liver1. The molecular weights of components _A_ and _B_ are 1.7 × 106 and 0.6 × 106, respectively. Although the study has yet to be extended to other systems, I suggested two years


ago that ribonucleic acids with molecular weights of about 1.7 × 106 exist in the cytoplasm of many types of cells3. The question that naturally arises is whether ribonucleic acids of such a


molecular weight also exist in a nucleus. So far no investigation along this line has been reported. The results presented below appear to provide an answer to the question. Access through


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BEING VIEWED BY OTHERS NEAR-IDENTICAL MACROMOLECULES SPONTANEOUSLY PARTITION INTO CONCENTRIC CIRCLES Article 04 December 2024 THE STRUCTURE OF A VIRUS-ENCODED NUCLEOSOME Article 29 April


2021 THE NUCLEOLUS AS A MULTIPHASE LIQUID CONDENSATE Article 01 September 2020 REFERENCES * Gierer, A., _Z. Naturforsch._, 136, 788 (1958). Article  Google Scholar  * Cheng, Ping-yao,


_Biochim. Biophys. Acta_ (to be published). * Cheng, Ping-yao, _Nature_, 179, 426 (1957). Article  ADS  CAS  Google Scholar  * Allfrey, V. G., Mirsky, A. E., and Osawa, S., _J. Gen.


Physiol._, 40, 451 (1957). Article  CAS  Google Scholar  * Dische, Z., _Mikrochemie_, 8, 4 (1930). Article  CAS  Google Scholar  * Dische, Z., _J. Biol. Chem._, 204, 983 (1953). CAS  Google


Scholar  * Cheng, Ping-yap, _Nature_, 181, 1800 (1958). Article  ADS  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Rockefeller Foundation Virus


Laboratories, New York, 21 PING-YAO CHENG Authors * PING-YAO CHENG View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and


permissions ABOUT THIS ARTICLE CITE THIS ARTICLE CHENG, PY. High Molecular Weight Ribonucleic Acids from the Nuclei of Calf Thymus. _Nature_ 184, 190–191 (1959).


https://doi.org/10.1038/184190a0 Download citation * Issue Date: 18 July 1959 * DOI: https://doi.org/10.1038/184190a0 SHARE THIS ARTICLE Anyone you share the following link with will be able


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