Incidence and outcome of idiopathic pneumonia syndrome in pediatric stem cell transplant recipients

ABSTRACT Idiopathic pneumonia syndrome (IPS) is a rare complication following stem cell transplant (SCT) and its incidence among pediatric SCT recipients is not known. To assess the

incidence of IPS, we retrospectively reviewed the incidence of IPS at our center. IPS is defined as the presence of multilobar infiltrates by chest radiograph or computed tomography scan,

need for supplemental oxygenation with declining pulse oximetry and no identifiable pulmonary infection. Between July 1999 and August 2005, 11 of 93 children who received a fully ablative

allogeneic SCT (11.8%) developed IPS. All 11 patients had normal pulmonary evaluation before transplant. IPS developed at a median of 17 days (range 8–42 days) after transplant. Recipients

of unrelated donor transplant had increased risk of developing IPS. There was a significant association between acute or hyperacute graft-versus-host disease (GVHD) and IPS (_P_=0.035). All

patients had significant hypoxia and five patients required assisted ventilation. IPS was the cause of death in two patients. Although there was complete resolution of respiratory symptoms

in the other nine patients, overall transplant-related mortality was significantly higher among patients with IPS (64 vs 17%, _P_=0.002). IPS is a relatively common complication in pediatric

SCT recipients and acute GVHD is an important associated factor. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution

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about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS LATE-ONSET PULMONARY COMPLICATIONS FOLLOWING ALLOGENEIC HEMATOPOIETIC CELL

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AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Pediatric Stem Cell Transplant Program, Vanderbilt Children's Hospital, Vanderbilt University, Nashville, TN, USA J Keates-Baleeiro, B

Manes, C Calder & H Frangoul * Department of Pediatric Pulmonary, Vanderbilt University, Nashville, TN, USA P Moore * Department of Biostatistics, Vanderbilt University, Nashville, TN,

USA T Koyama Authors * J Keates-Baleeiro View author publications You can also search for this author inPubMed Google Scholar * P Moore View author publications You can also search for this

author inPubMed Google Scholar * T Koyama View author publications You can also search for this author inPubMed Google Scholar * B Manes View author publications You can also search for this

author inPubMed Google Scholar * C Calder View author publications You can also search for this author inPubMed Google Scholar * H Frangoul View author publications You can also search for

this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to H Frangoul. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Keates-Baleeiro,

J., Moore, P., Koyama, T. _et al._ Incidence and outcome of idiopathic pneumonia syndrome in pediatric stem cell transplant recipients. _Bone Marrow Transplant_ 38, 285–289 (2006).

https://doi.org/10.1038/sj.bmt.1705436 Download citation * Received: 11 April 2006 * Revised: 02 May 2006 * Accepted: 04 June 2006 * Published: 03 July 2006 * Issue Date: 01 August 2006 *

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currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * idiopathic * pneumonia * transplant * children