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SUMMARY: The present multimodal treatment approach was designed to achieve prolonged tumor control in advanced gastric cancer. A total of 26 patients with stage IV gastric cancer (metastatic
disease _n_=25), ECOG performance status 0–3 and laparoscopically evaluated peritoneal status received a modified EAP schedule to prove chemosensitivity and to mobilize autologous
peripheral blood stem cells (aPBSC). Patients without progressive disease proceeded to tandem high-dose chemotherapy (HD-CT) and aPBSCT. Patients with >50% reduction of the target lesion
received a second cycle of HD-CT. Responders were selected for local R0 resections (D2 resection) according clinical criteria. Of 26 patients, 20(77%) achieved partial remission after
dose-intensive chemotherapy: local R0 resection was achieved in 12 out of 14 patients selected for surgery (46% of all patients). Eight of these R0-resected patients initially had peritoneal
carcinomatosis. With a median follow-up of 3.2 years, four patients are still alive. The median overall survival was 8.4 months (CI 2.5–14.4 months), for histologic regression grade 3
(seven out of 25 patients, 28%) 29 months (CI 12–46 months). The combined treatment approach is tolerable and feasible in advanced disease and opens a therapeutic window for a significant
proportion of patients, even in cases with histologically proven peritoneal carcinomatosis. Access through your institution Buy or subscribe This is a preview of subscription content, access
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Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS NEOADJUVANT SINTILIMAB IN COMBINATION WITH CONCURRENT
CHEMORADIOTHERAPY FOR LOCALLY ADVANCED GASTRIC OR GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA: A SINGLE-ARM PHASE 2 TRIAL Article Open access 14 August 2023 A PHASE II RANDOMISED TRIAL OF
INDUCTION CHEMOTHERAPY FOLLOWED BY CONCURRENT CHEMORADIOTHERAPY IN LOCALLY ADVANCED PANCREATIC CANCER: THE TAIWAN COOPERATIVE ONCOLOGY GROUP T2212 STUDY Article 17 December 2021 NEOADJUVANT
CAMRELIZUMAB AND APATINIB COMBINED WITH CHEMOTHERAPY VERSUS CHEMOTHERAPY ALONE FOR LOCALLY ADVANCED GASTRIC CANCER: A MULTICENTER RANDOMIZED PHASE 2 TRIAL Article Open access 02 January 2024
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of Hematology and Oncology, University of Regensburg, Germany A Reichle, H Wagner, M Zaiss & R Andreesen * Department of Surgery, University of Regensburg, Germany U Bolder & K-W
Jauch * Department of Gastroenterology, University of Regensburg, Germany H Messmann * Department of Pathology, University of Regensburg, Germany F Bataille, P Wild & F Hofstädter
Authors * A Reichle View author publications You can also search for this author inPubMed Google Scholar * U Bolder View author publications You can also search for this author inPubMed
Google Scholar * F Bataille View author publications You can also search for this author inPubMed Google Scholar * H Messmann View author publications You can also search for this author
inPubMed Google Scholar * H Wagner View author publications You can also search for this author inPubMed Google Scholar * M Zaiss View author publications You can also search for this author
inPubMed Google Scholar * P Wild View author publications You can also search for this author inPubMed Google Scholar * F Hofstädter View author publications You can also search for this
author inPubMed Google Scholar * R Andreesen View author publications You can also search for this author inPubMed Google Scholar * K-W Jauch View author publications You can also search for
this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to A Reichle. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Reichle, A.,
Bolder, U., Bataille, F. _et al._ A multimodal treatment approach including high-dose chemotherapy in very advanced gastric cancer: evidence for control of metastatic disease. _Bone Marrow
Transplant_ 32, 665–671 (2003). https://doi.org/10.1038/sj.bmt.1704203 Download citation * Received: 26 November 2002 * Accepted: 13 March 2003 * Published: 16 September 2003 * Issue Date:
01 October 2003 * DOI: https://doi.org/10.1038/sj.bmt.1704203 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a
shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * advanced gastric cancer *
multimodal treatment * neoadjuvant chemotherapy