Successful treatment of refractory t-cell acute lymphoblastic leukemia by unmanipulated stem cell transplantation from an hla 3-loci mismatched (haploidentical) sibling

SUMMARY: We describe a patient with refractory T-cell acute lymphoblastic leukemia who successfully underwent unmanipulated stem cell transplantation from an HLA 3-loci mismatched

(haploidentical) sibling. In order to avoid severe graft-versus-host disease (GVHD), we used intensified GVHD prophylaxis consisting of tacrolimus, a short course of methotrexate,

methylprednisolone, and mycophenolate mofetil. Hematopoietic reconstitution was rapid, with neutrophil count >5 × 108/l on day +16, and platelet count >2 × 1010/l on day +25. There was

no evidence of clinical acute GVHD. Bacterial, fungal, and viral infections were well controlled with antibiotics. The patient is still in complete remission past day +400. We suggest that

unmanipulated HLA-mismatched transplantation with intensified GVHD prophylaxis is an alternative option for patients who do not have an HLA-identical donor. Access through your institution

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AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Molecular Medicine, Osaka University Graduate School of Medicine, Japan K Ikegame, Y Tanji, N Kitai, H Tamaki, M Kawakami, T

Fujioka, Y Oka & H Ogawa * HLA Laboratory, Kyoto, Japan E Maruya & H Saji * Department of Clinical Laboratory Science, Osaka University Medical School, Japan H Sugiyama Authors * K

Ikegame View author publications You can also search for this author inPubMed Google Scholar * Y Tanji View author publications You can also search for this author inPubMed Google Scholar *

N Kitai View author publications You can also search for this author inPubMed Google Scholar * H Tamaki View author publications You can also search for this author inPubMed Google Scholar *

M Kawakami View author publications You can also search for this author inPubMed Google Scholar * T Fujioka View author publications You can also search for this author inPubMed Google

Scholar * Y Oka View author publications You can also search for this author inPubMed Google Scholar * E Maruya View author publications You can also search for this author inPubMed Google

Scholar * H Saji View author publications You can also search for this author inPubMed Google Scholar * H Sugiyama View author publications You can also search for this author inPubMed 

Google Scholar * H Ogawa View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS

ARTICLE Ikegame, K., Tanji, Y., Kitai, N. _et al._ Successful treatment of refractory T-cell acute lymphoblastic leukemia by unmanipulated stem cell transplantation from an HLA 3-loci

mismatched (haploidentical) sibling. _Bone Marrow Transplant_ 31, 507–510 (2003). https://doi.org/10.1038/sj.bmt.1703858 Download citation * Published: 28 March 2003 * Issue Date: 01 March

2003 * DOI: https://doi.org/10.1038/sj.bmt.1703858 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link

is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * ALL * HLA-mismatched BMT * GVHD * FK506 *

methylprednisolone * mycophenolate mofetil