Polyoma viruria following t-cell-depleted allogeneic transplants using campath-1h: incidence and outcome in relation to graft manipulation, donor type and conditioning

SUMMARY: Haemorrhagic cystitis (HC) is an important cause of morbidity following stem cell transplantation (SCT) and has been associated with polyoma virus infection. We studied the

incidence and outcome of polyoma virus infection in 58 T-cell-depleted SCT patients. T-cell depletion was carried out using Campath-1H, either 10 or 20 mg _in vitro_ (_n_=33) or 50 or 100 mg

_in vivo_ (_n_=25) following conventional (_n_=35) or nonmyeloablative conditioning (_n_=23). A total of 21 patients (36%) had polyoma viruria at a median of 35 days (5–114); 30% among

patients receiving Campath _in vitro_ and 44% among those given _in vivo_. The only risk factor for polyoma viruria was graft-versus-host disease GVHD grade ⩾2. The onset of polyoma viruria

coincided with Cytomegalovirus (CMV) reactivation in all six patients who reactivated both viruses. Prolonged viruria (defined as polyoma viruria >2 weeks) was documented in 10 patients

(17%) and this was associated with GVHD ⩾grade 2. HC occurred in four patients. Prolonged viruria was associated with HC only in patients receiving unrelated donor grafts following

conventional conditioning. HC was not observed following nonmyeloablative conditioning despite a higher incidence of prolonged viruria. Thus, HC was uncommon in patients with polyoma viruria

following T-cell depletion with Campath, particularly after reduced intensity conditioning. Access through your institution Buy or subscribe This is a preview of subscription content,

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Professor H Waldmann and the staff of the Therapeutic Antibody Centre, University of Oxford for their contributions to the production of CAMPATH-1H antibody. Their work was supported by the

United Kingdom Medical Research Council, Leukosite Inc and the EP Abraham's Trust. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Departments of Haematology, Birmingham Heartlands

Hospital, Birmingham, UK S Chakrabarti & D W Milligan * Public Health Laboratory Birmingham Heartlands Hospital, Birmingham, UK H Osman & K Collingham Authors * S Chakrabarti View

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RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Chakrabarti, S., Osman, H., Collingham, K. _et al._ Polyoma viruria following T-cell-depleted allogeneic

transplants using Campath-1H: incidence and outcome in relation to graft manipulation, donor type and conditioning. _Bone Marrow Transplant_ 31, 379–386 (2003).

https://doi.org/10.1038/sj.bmt.1703847 Download citation * Received: 14 June 2002 * Accepted: 12 August 2002 * Published: 12 March 2003 * Issue Date: 01 March 2003 * DOI:

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currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * polyomavirus * T-cell depletion * transplantation