Faster neutrophil and platelet engraftment, but no differences in acute gvhd or survival, using peripheral blood stem cells from related and unrelated donors, compared to bone marrow

ABSTRACT In this retrospective study, 23 recipients of peripheral blood progenitor cells (PBPC) were compared to 23 recipients of bone marrow (BM). The donors were 12 HLA-A-B-DR identical

siblings and 11 HLA-A-B-DR identical unrelated donors in the PBPC and BM groups, respectively. Diagnoses in the PBPC group were CML seven, AML nine, ALL three, lymphoma one, myeloma two and

aspartylglucosaminuria (AGU) one. The median age was 40 (5–55) years. The BM group was matched for diagnosis, age, conditioning therapy, GVHD prophylaxis and G-CSF treatment after BMT. A

higher number of MNC (_P_ < 0.001), cd34+ (_P_ = 0.05), CD3+ (_P_ < 0.001) and cd56+ (_P_ < 0.001) cells in the graft, a reduced number of platelet transfusions (_P_ = 0.03) and a

significant hastening of neutrophil and platelet recovery were seen in the PBPC group compared to the BM group. In logistic regression analysis, the following factors were important for

engraftment of ANC >0.5 × 109/l: peripheral blood progenitor cell transplantation (PBPCT) (_P_ = 0.003) and mononuclear cells (MNC) ⩾2.5 × 108/kg recipient in the graft (above median)

(_P_ = 0.009) in univariate analysis. For recovery of platelets >30 × 109/l: PBPCT (_P_ = 0.03) and HLA-identical sibling donors (_P_ = 0.05) were significant in multivariate analysis. A

trend towards a lower incidence of bacteremia was seen in the PBPC group, ie 22 _vs_ 48% (_P_ = 0.06) in the BM group. GVHD, TRM and survival did not differ between the two groups. Access

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NETWORK FOR BLOOD AND MARROW TRANSPLANTATION Article 07 October 2024 AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Transplantation Surgery, Huddinge Hospital, Huddinge, Sweden

H Hägglund & O Ringdén * Department of Clinical Immunology, Huddinge Hospital, Huddinge, Sweden O Ringdén, M Remberger & L Tammik * Department of Hematology, Huddinge Hospital,

Huddinge, Sweden B Lönnqvist * Department of Infectious Diseases, Huddinge Hospital, Huddinge, Sweden E Sparrelid * Department of The Blood Bank, Huddinge Hospital, Huddinge, Sweden G

Kumlien Authors * H Hägglund View author publications You can also search for this author inPubMed Google Scholar * O Ringdén View author publications You can also search for this author

inPubMed Google Scholar * M Remberger View author publications You can also search for this author inPubMed Google Scholar * B Lönnqvist View author publications You can also search for this

author inPubMed Google Scholar * E Sparrelid View author publications You can also search for this author inPubMed Google Scholar * L Tammik View author publications You can also search for

this author inPubMed Google Scholar * G Kumlien View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT

THIS ARTICLE CITE THIS ARTICLE Hägglund, H., Ringdén, O., Remberger, M. _et al._ Faster neutrophil and platelet engraftment, but no differences in acute GVHD or survival, using peripheral

blood stem cells from related and unrelated donors, compared to bone marrow. _Bone Marrow Transplant_ 22, 131–136 (1998). https://doi.org/10.1038/sj.bmt.1701298 Download citation * Received:

30 January 1998 * Accepted: 03 March 1998 * Published: 13 July 1998 * Issue Date: 01 July 1998 * DOI: https://doi.org/10.1038/sj.bmt.1701298 SHARE THIS ARTICLE Anyone you share the

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Nature SharedIt content-sharing initiative KEYWORDS * allogeneic peripheral blood progenitor cell transplantation * bone marrow transplantation * engraftment * graft-versus-host disease *

survival