The use of an expanded circulating hematopoietic progenitor cell pool associated with bone marrow fibrosis for the support of autologous transplantation in igd multiple myeloma

ABSTRACT Leukoerythroblastosis and myelofibrosis were observed at presentation in a patient with IgD myeloma. Interestingly, a 1000-fold increase in peripheral blood progenitor cells (PBPC)

was found in the steady state without signs of any underlying myeloproliferative disorder. The myeloma was resistant to conventional therapy. The expanded PBPC were collected in the steady

state and used to support two consecutive myeloablative courses. A complete remission of the myeloma was achieved, with resolution of myelofibrosis. Furthermore, the unprimed PBPC expanded

as a result of myelofibrosis, provided a sustained hematopoietic reconstitution. This indicated that their hematopoietic potential was equivalent to that of PBPC mobilized by chemotherapy or

growth factors. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution

Subscribe to this journal Receive 12 print issues and online access $259.00 per year only $21.58 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full

article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs *

Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS SALVAGE TREATMENT WITH PLERIXAFOR IN POOR MOBILIZING ALLOGENEIC STEM CELL DONORS: RESULTS OF A PROSPECTIVE PHASE II-TRIAL

Article Open access 07 October 2020 MOBILIZATION STRATEGIES WITH AND WITHOUT PLERIXAFOR FOR AUTOLOGOUS STEM CELL TRANSPLANT IN PATIENTS WITH MULTIPLE MYELOMA Article 31 July 2024 IMPACT OF

SINGLE DOSE OF PEGFILGRASTIM ON PERIPHERAL BLOOD STEM CELL HARVEST IN PATIENTS WITH MULTIPLE MYELOMA OR MALIGNANT LYMPHOMA Article Open access 25 April 2025 AUTHOR INFORMATION AUTHORS AND

AFFILIATIONS * Servicio de Hematología, Hospital Universitario 12 de Octubre, Madrid, Spain J de la Serna, R Bornstein & J-J Lahuerta-Palacios Authors * J de la Serna View author

publications You can also search for this author inPubMed Google Scholar * R Bornstein View author publications You can also search for this author inPubMed Google Scholar * J-J

Lahuerta-Palacios View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE de

la Serna, J., Bornstein, R. & Lahuerta-Palacios, JJ. The use of an expanded circulating hematopoietic progenitor cell pool associated with bone marrow fibrosis for the support of

autologous transplantation in IgD multiple myeloma. _Bone Marrow Transplant_ 19, 1033–1036 (1997). https://doi.org/10.1038/sj.bmt.1700784 Download citation * Received: 14 October 1996 *

Accepted: 02 February 1997 * Issue Date: 01 May 1997 * DOI: https://doi.org/10.1038/sj.bmt.1700784 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this

content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative

KEYWORDS * IgD myeloma * myelofibrosis * peripheral blood stem cell transplantation