Serotonin1a receptor activation by flesinoxan in humans

ABSTRACT The effects of the selective 5-HT1A receptor agonist flesinoxan on neuroendocrine function, temperature, and behavior were assessed in male healthy volunteers using a double-blind,

placebo-controlled crossover design. Flexinoxan (7 and 14 μg/kg), administered intravenously in 11 healthy volunteers, elicited a dose-related decrease in body temperature and increases in

growth hormone, adrenocorticotropic hormone (ACTH), cortisol, and prolactin plasma levels. In a second independent study, 12 healthy volunteers were pretreated sequentially, at one-week

intervals, with either the 5-HT1A antagonist pindolol (30 mg, PO), the nonselective 5-HT1 2 antagonist methysergide (4 mg, PO), or placebo, prior to being administered flesinoxan (1 mg, IV).

The growth hormone response to flesinoxan was blocked by pindolol but not by methysergide, whereas the prolactin response was blocked by methysergide but not by pindolol. The ACTH and

cortisol responses to flesinoxan were potentiated by methysergide. The flesinoxan-induced hypothermia was attenuated by both methysergide and pindolol, although the latter effects did not

reach statistical significance. The present results suggest that the growth hormone response and the hypothermic response to the intravenous infusion of flesinoxan may serve as a valid index

of 5-HT1A receptor function in humans. SIMILAR CONTENT BEING VIEWED BY OTHERS ACUTE DOSE-DEPENDENT EFFECTS AND SELF-GUIDED TITRATION OF CONTINUOUS _N,N-_DIMETHYLTRYPTAMINE INFUSIONS IN A

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ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Psychiatry, Neurobiological Psychiatry Unit, McGill University, Montreal, H3A 1A1, Canada B Seletti MD, C Benkelfat

MD, P Blier MD, Ph.D, L Annable B.Sc, F Gilbert MD & C de Montigny MD, Ph.D * the Department of Endocrinology, Maisonneuve-Rosemont Hospital, Montreal, H1T 2M4, Canada B Seletti MD, C

Benkelfat MD, P Blier MD, Ph.D, L Annable B.Sc, F Gilbert MD & C de Montigny MD, Ph.D Authors * B Seletti MD View author publications You can also search for this author inPubMed Google

Scholar * C Benkelfat MD View author publications You can also search for this author inPubMed Google Scholar * P Blier MD, Ph.D View author publications You can also search for this author

inPubMed Google Scholar * L Annable B.Sc View author publications You can also search for this author inPubMed Google Scholar * F Gilbert MD View author publications You can also search for

this author inPubMed Google Scholar * C de Montigny MD, Ph.D View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and

permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Seletti, B., Benkelfat, C., Blier, P. _et al._ Serotonin1A Receptor Activation by Flesinoxan in Humans. _Neuropsychopharmacol_ 13, 93–104

(1995). https://doi.org/10.1016/0893-133X(95)00025-9 Download citation * Received: 31 August 1994 * Revised: 10 January 1995 * Accepted: 27 January 1995 * Published: 01 October 1995 * Issue

Date: 01 October 1995 * DOI: https://doi.org/10.1016/0893-133X(95)00025-9 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link

Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * Flesinoxan * Hypothermia

* Growth hormone * Pindolol * Methysergide * 5-HT1A receptor