Ambivalent role of bcl6 in cell survival and transformation

ABSTRACT The _BCL6_ gene is often structurally altered and probably ‘misregulated’ in two different types of human B-cell non-Hodgkin lymphomas (BNHL) thought to arise from germinal centre B

cells. _BCL6_ encodes a BTB/POZ and zinc finger protein whose biochemical properties support a role as a DNA-binding transcriptional repressor and disclose, in part, the underlying

mechanisms. In contrast, the study of the ‘oncogenic’ structural alterations of _BCL6_ in BNHL and of its cellular functions gives rise to much more heterogeneous data with no obvious

unifying picture so that how and even whether _BCL6_ contributes to lymphomagenesis remains unclear. This review will summarize the current knowledge about the ‘oncogenic’ alterations and

cellular functions of _BCL6_ and, based on some results, will propose the following hypotheses: (1) In various systems, including in memory T cells and also in germinal centre B cells and

possibly in certain postmitotic cells, BCL6 may act by stabilizing a particular stage of differentiation. (2) Both its ambivalent effects on cell survival and the heterogeneous consequences

of its alterations in BNHL suggest that _BCL6_ can be oncogenic not only upon overexpression or persistent expression, as often proposed, but also, similar to some of its relatives, upon

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FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS FREQUENT MUTATIONS IN THE AMINO-TERMINAL DOMAIN OF BCL7A IMPAIR ITS TUMOR SUPPRESSOR ROLE IN DLBCL Article 24 June

2020 DELETION OF THE TRANSCRIPTIONAL REGULATOR TFAP4 ACCELERATES C-MYC-DRIVEN LYMPHOMAGENESIS Article Open access 09 March 2023 GENETIC AND EPIGENETIC DETERMINANTS OF DIFFUSE LARGE B-CELL

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Biophys. Acta._, 1540, 188–200. Download references ACKNOWLEDGEMENTS I warmly thank Dr Alex Dent for insightful comments and sharing unpublished data, Drs Takeshi Tokuhisa, Alex Dent, Yuichi

Nakamura, Hélène Pelczar and Patrick Martin for a critical reading of the manuscript, and to Dr Christophe Pivot-Pajot for suggestions. I am also very grateful to Dr Sophie Green-Rousseaux

for her precious help with the language. This work was supported by grants from Centre National de la Recherche Scientifique (CNRS), Association pour la Recherche sur le Cancer (ARC) and

Ligue contre le Cancer, comité du Val de Marne. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * CNRS UPR 1983, Institut André Lwoff, 7 rue Guy Môquet, BP8, Villejuif, 94801, France Olivier

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_Oncogene_ 22, 507–516 (2003). https://doi.org/10.1038/sj.onc.1206152 Download citation * Received: 16 July 2002 * Revised: 11 October 2002 * Accepted: 21 October 2002 * Published: 29

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B-cell lymphoma * Germinal centre * cell survival * apoptosis