Hematopoietic cytokines, transcription factors and lineage commitment

ABSTRACT The past two decades have witnessed significant advances in our understanding of the cellular physiology and molecular regulation of hematopoiesis. At the heart of stem cell

self-renewal and lineage commitment decisions lies the relative expression levels of lineage-specific transcription factors. The expression of these transcription factors in early stem cells

may be promiscuous and fluctuate, but ultimately comes under the influence of extracellular regulatory signals in the form of hematopoietic cytokines. In this review, we first summarize our

current understanding of the phenotypic characterization of hematopoietic stem cells. Next, we describe key known transcription factors which govern stem cell self-renewal and lineage

commitment decisions. Finally, we review data concerning the role of specific cytokines in influencing these decisions. From this review, a picture emerges in which stem cell fate decisions

are governed by the integrated effects of intrinsic transcription factors and external signaling pathways initiated by regulatory cytokines. Access through your institution Buy or subscribe

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HEMATOPOIETIC STEM AND PROGENITOR CELL SIGNALING IN THE NICHE Article 19 October 2020 DISCRETE REGULATORY MODULES INSTRUCT HEMATOPOIETIC LINEAGE COMMITMENT AND DIFFERENTIATION Article Open

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AFFILIATIONS * Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104, Pennsylvania, PA, USA Jiang Zhu & Stephen G Emerson * Department of Pediatrics,

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currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * transcription factor * cytokines * hematopoiesis