Cd95 mediated t cell apoptosis and its relevance to immune deviation


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ABSTRACT The CD95/CD95L pair plays a manifold role in regulating life and death in the function of the immune system. Examples include CD95/CD95L acting as cytotoxic CD8+ T cell effector


molecules, or functioning on CD4+ T helper cells to maintain peripheral tolerance or reestablishing homeostasis. Current understanding of the CD95 signaling pathway reveals several potential


regulatory targets, acting both receptor proximally and distally, that can terminate or amplify the receptor's signal. The important and possibly non-redundant role of CD95 is


highlighted both in how deficiencies in functional CD95 or its ligand manifest themselves in autoimmune syndromes, and how uncontrolled cell death results in insufficient, or inappropriate


immune responses against immune challenge. This review examines CD95-mediated signal transduction, and the effect preferential apoptosis of T helper cell subsets has on immune system


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support SIMILAR CONTENT BEING VIEWED BY OTHERS T CELLS IN HEALTH AND DISEASE Article Open access 19 June 2023 RETHINKING PERIPHERAL T CELL TOLERANCE: CHECKPOINTS ACROSS A T CELL’S JOURNEY


Article 19 October 2020 BYSTANDER CD4+ T CELLS: CROSSROADS BETWEEN INNATE AND ADAPTIVE IMMUNITY Article Open access 28 August 2020 AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of


Microbiology and Immunology, Temple University School of Medicine, Philadelphia, 19140, Pennsylvania, USA Arun S Varadhachary & Padmini Salgame Authors * Arun S Varadhachary View author


publications You can also search for this author inPubMed Google Scholar * Padmini Salgame View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND


PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Varadhachary, A., Salgame, P. CD95 mediated T cell apoptosis and its relevance to immune deviation. _Oncogene_ 17,


3271–3276 (1998). https://doi.org/10.1038/sj.onc.1202572 Download citation * Published: 12 January 1999 * Issue Date: 24 December 1998 * DOI: https://doi.org/10.1038/sj.onc.1202572 SHARE


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clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * T cells * CD95 * immune * deviation