T(6;8), t(8;9) and t(8;13) translocations associated with stem cell myeloproliferative disorders have close or identical breakpoints in chromosome region 8p11-12

ABSTRACT A stem-cell myeloproliferative disorder involving T- and B-cell, and myeloid lineages, is associated with three different translocations with a breakpoint in region p11-12 of

chromosome 8: t(6;8)(q27;p11), t(8;9)(p11;q33), and t(8;13)(p12;q12), respectively. Using fluorescence _IN SITU_ hybridization (FISH), we have analysed blood cells from a series of five

patients carrying these different translocations. We have identified cosmids from chromosome region 8p11-12 that span the breakpoint in all the cases. They are specific for the _FGFR1_ gene

that encodes a receptor for members of the FGF family. The breakpoint was further detected by Southern and pulsed-field gel electrophoresis analyses with probes from the _FGFR1_ locus.

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support SIMILAR CONTENT BEING VIEWED BY OTHERS CHROMOTHRIPSIS IS A FREQUENT EVENT AND UNDERLIES TYPICAL GENETIC CHANGES IN EARLY T-CELL PRECURSOR LYMPHOBLASTIC LEUKEMIA IN ADULTS Article

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October 2020 GENOMIC VARIATIONS IN PATIENTS WITH MYELODYSPLASTIC SYNDROME AND KARYOTYPES WITHOUT NUMERICAL OR STRUCTURAL CHANGES Article Open access 02 February 2021 AUTHOR INFORMATION

Author notes * Max Chaffanet and Cornel Popovici: These authors have equally contributed to the work AUTHORS AND AFFILIATIONS * Laboratoire d'Oncologie Moléculaire, U.119 INSERM,

Institut de Cancérologie et d'Immunologie de Marseille, 27Bd leïRoure, Marseille, 13009, France Max Chaffanet, Cornel Popovici, Marina Lafage-Pochitaloff, Daniel Birnbaum & 

Marie-Josèphe Pébusque * Laboratoire de Biologie des Tumeurs, Institut Paoli-Calmettes (IPC), Marseille, France Max Chaffanet, José Adélaïde & Daniel Birnbaum * Groupe de Recherche sur

les Lymphomes, Institut Albert Bonniot, Université J. Fourier, Grenoble, France Dominique Leroux & Michèle Jacrot * Laboratoire d'Hématologie, Génétique des Hémopathies, Hôpital de

Purpan, Toulouse, France Nicole Dastugue * Laboratoire de Génétique, Centre Hospitalier Universitaire, Nancy, France Marie-José Grégoire * Center for Human Genetics, University of Leuven,

Leuven, Belgium Anne Hagemeijer * Département d'Hématologie, Laboratoire de Cytogénétique, IPC, Marseille, France Marina Lafage-Pochitaloff Authors * Max Chaffanet View author

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AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Chaffanet, M., Popovici, C., Leroux, D. _et al._ t(6;8), t(8;9) and t(8;13) translocations associated with stem

cell myeloproliferative disorders have close or identical breakpoints in chromosome region 8p11-12. _Oncogene_ 16, 945–949 (1998). https://doi.org/10.1038/sj.onc.1201601 Download citation *

Received: 23 March 1997 * Revised: 25 September 1997 * Accepted: 26 September 1997 * Published: 03 March 1998 * Issue Date: 19 February 1998 * DOI: https://doi.org/10.1038/sj.onc.1201601

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clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * _FGFR1_ gene * leukemia * lymphoma * human chromosome pairs 6, 8, 9, 13 * translocation *

fluorescence _in situ_ hybridization * stem cell * hematopoiesis