The influence of hemodynamic factors on left ventricular mass

Access through your institution Buy or subscribe WE EVALUATED THE RELATIONSHIP BETWEEN THE VARIABILITY IN THE LEFT VENTRICULAR MASS INDEX (LVMI) AND DIFFERENT HEMODYNAMIC FACTORS. LVMI WAS

ASSOCIATED WITH BLOOD PRESSURE AND, IN ONE SUBGROUP, STRONGLY TO ARTERIAL PULSE WAVE VELOCITY (PWV). HIGH PHYSICAL ACTIVITY WAS CONNECTED TO INCREASED LVMI, AND A COMBINATION OF LOW STROKE

INDEX (SI) AND HIGH HEART RATE (HR) TO DECREASED LVMI. Left ventricular hypertrophy (LVH) is an independent predictor of cardiovascular mortality and morbidity, and it is, actually, a

stronger risk factor than blood pressure (BP), smoking or cholesterol.1 Several hemodynamic and non-hemodynamic factors are associated with LVH. Regarding hemodynamic and demographic

factors, the most important independent determinants of the left ventricular mass (LVM) among Chinese have been shown to be stroke volume (SV), systolic arterial pressure (SBP), end-systolic

meridional stress to volume ratio (representing myocardial contractility), aortic root diameter and body mass index (BMI).2 The Strong Heart Study with American Indian participants

suggested that SV, contractility index and SBP are somewhat equal and best independent correlates of LVM.3 Arterial stiffness can be estimated by measuring the arterial PWV. Arterial

stiffening is considered an adverse change, since it is related to all-cause and cardiovascular morbidity and mortality in hypertensive patients.4 There are insufficient data about arterial

stiffness as a predictor of LVM. In a large population study, indices of arterial stiffness did not appear to be independent determinants of LVM in multiple regression models.2 The aim of

the present investigation was to study the influence of hemodynamic and non-hemodynamic factors on LVM. Ninety-seven men aged 35–45 years were recruited to an ambulatory BP study between

1987 and 1990 from routine primary care health check-up in the City of Tampere. The study group included 34 normotensive, 29 borderline hypertensive and 34 hypertensive when classified

according to WHO criteria. This current study is a cross-sectional survey after an average follow-up of 10.8 years. Eighty-seven men were available for the present study. Twenty of them were

excluded, because they were on antihypertensive medication. The basic characteristics of the study population have been published previously.5 The local ethical committee approved the study

protocol and all patients gave informed consent. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this

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Dial Transplant_ 2003; 18: 2332–2338. Article  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Clinical Physiology, Medical School,

University of Tampere, M P O Virtanen, M A P Kähönen, S K Majahalme, V M H Turjanmaa & T Kööbi * Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland M P O

Virtanen, M A P Kähönen, S K Majahalme, V M H Turjanmaa & T Kööbi * Department of Pharmacological Sciences, Medical School, University of Tampere, Tampere, Finland T Nieminen * Appleton

Heart Institute, Appleton, WI, USA S K Majahalme * Department of Psychology, University of Tampere, M T Tuomisto * Department of Psychiatry, Tampere University Hospital, Tampere, Finland M T

Tuomisto Authors * M P O Virtanen View author publications You can also search for this author inPubMed Google Scholar * T Nieminen View author publications You can also search for this

author inPubMed Google Scholar * M A P Kähönen View author publications You can also search for this author inPubMed Google Scholar * S K Majahalme View author publications You can also

search for this author inPubMed Google Scholar * M T Tuomisto View author publications You can also search for this author inPubMed Google Scholar * V M H Turjanmaa View author publications

You can also search for this author inPubMed Google Scholar * T Kööbi View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence

to M P O Virtanen. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Virtanen, M., Nieminen, T., Kähönen, M. _et al._ The influence of hemodynamic factors

on left ventricular mass. _J Hum Hypertens_ 22, 126–128 (2008). https://doi.org/10.1038/sj.jhh.1002267 Download citation * Published: 26 July 2007 * Issue Date: February 2008 * DOI:

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