Association of novel promoter single nucleotide polymorphisms in vasopressin v1a receptor gene with essential hypertension in nonobese japanese

Access through your institution Buy or subscribe WE STUDIED THE ASSOCIATION BETWEEN FOUR NOVEL SINGLE NUCLEOTIDE POLYMORPHISMS (SNPS) IN THE PROMOTER REGION OF V1AR GENE AND ESSENTIAL

HYPERTENSION IN 620 JAPANESE SUBJECTS (365 HYPERTENSIVES AND 255 HEALTHY). A SIGNIFICANT ASSOCIATION WAS FOUND BETWEEN ONE OF THE GENOTYPES AND ALLELES AT SNP −6951 AND HYPERTENSION IN A

SUBSAMPLE OF NONOBESE INDIVIDUALS. THIS ASSOCIATION DEMONSTRATED AN INDEPENDENT RISK FOR NONOBESE HYPERTENSION. Arginine vasopressin (AVP) plays an important role in cardiovascular

regulation. AVP acts on V1a receptor (V1aR) to increase vascular tone and baroreceptor sensitivity.1, 2 Extensive studies have been made in the search for the genetic basis of essential

hypertension.3 V1aR gene also represents a reasonable candidate for the study of its involvement in human essential hypertension. Recently, it has become evident that in clinically defined

subtypes of hypertension, obesity-associated hypertension may be genetically distinct from hypertension in nonobese individuals.4 Since an investigation of clinically defined subsets of

hypertension may facilitate the search for their specific genes, we explored whether the identified four novel single nucleotide polymorphisms (SNPs) of V1aR gene (−6951G/A, −4112A/T,

−3860T/C and −242C/T) could be associated with either obesity-associated hypertension or hypertension in nonobese individuals. This is a preview of subscription content, access via your

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Google Scholar  Download references ACKNOWLEDGEMENTS Support from the Ministry of Education, Science, Sports and Culture, Japan (Grant-in-Aid for Scientific Research No. 15590477 and No.

17590482). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Laboratory Medicine, Hirosaki University School of Medicine, Aomori, Japan K N Hasan, M Shoji & M Yasujima *

Department of Pharmacodynamics, Meiji Pharmaceutical University, Tokyo, Japan M Shoji * Department of Clinical Laboratory, Hirosaki University Hospital, Aomori, Japan K Sugimoto, S Tsutaya, 

E Matsuda & R Kudo * Department of Social Medicine, Hirosaki University School of Medicine, Aomori, Japan S Nakaji * Third Department of Internal Medicine, Hirosaki University School of

Medicine, Aomori, Japan T Suda Authors * K N Hasan View author publications You can also search for this author inPubMed Google Scholar * M Shoji View author publications You can also search

for this author inPubMed Google Scholar * K Sugimoto View author publications You can also search for this author inPubMed Google Scholar * S Tsutaya View author publications You can also

search for this author inPubMed Google Scholar * E Matsuda View author publications You can also search for this author inPubMed Google Scholar * R Kudo View author publications You can also

search for this author inPubMed Google Scholar * S Nakaji View author publications You can also search for this author inPubMed Google Scholar * T Suda View author publications You can also

search for this author inPubMed Google Scholar * M Yasujima View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to M

Shoji. ADDITIONAL INFORMATION Supplementary Information accompanies the paper on the Journal of Human Hypertension website (http://www.nature.com/jhh). SUPPLEMENTARY INFORMATION

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Hasan, K., Shoji, M., Sugimoto, K. _et al._ Association of novel promoter single nucleotide polymorphisms in vasopressin V1a receptor gene with essential hypertension in nonobese Japanese.

_J Hum Hypertens_ 21, 825–827 (2007). https://doi.org/10.1038/sj.jhh.1002227 Download citation * Published: 26 July 2007 * Issue Date: 01 October 2007 * DOI:

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