Incidence of diabetes and gout in hypertensive patients during 8 years of follow-up

ABSTRACT Hypertension has been shown to be closely associated with metabolic disorders such as diabetes mellitus and gout. The aim of this study was to establish the incidence of both these

diseases in hypertensive patients and their age-matched controls and to assess the risk associated with diuretic treatment. The results refer to the data base of 2295 hypertensive and 2280

controls from the General Practice Hypertension Study Group who were screened for hypertension. The rescreened hypertensive subjects (_n_ = 1190) and their controls (_n_ = 938) were followed

for an average of 8 years. The diagnosis of diabetes and gout was made by their general practitioners. After 8 years of follow-up, diabetes mellitus was diagnosed in 5.0% of hypertensive

and 1.5% normotensive subjects. The diagnosis of gout was made in 3.1% and 0.9%, respectively. Moreover, diabetes mellitus occurred more frequently in both hypertensive men and women, with

diuretic treatment and without (respectively, men given diuretic: relative risk (RR) = 2.74, 95% confidence interval (CI): 0.99, 7.5; and men not given diuretic: RR = 2.25, 95% CI: 1.0, 5.3:

women RR = 4.03 95% CI: 1.5, 10.8, and RR = 3.47, 95% CI: 1.4, 8.9) in comparison with their age-matched controls. For gout the excess was confirmed in hypertensive men with and without

diuretic treatment (RR = 6.25 (95% CI: 2.4, 16.7) _vs_ 3.93 (95% CI: 1.6, 9.7)). Access through your institution Buy or subscribe This is a preview of subscription content, access via your

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* Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Royal Postgraduate Medical School, London, UK T

Grodzicki, A Palmer & CJ Bulpitt * Jagiellonian University, Cracow, Poland T Grodzicki Authors * T Grodzicki View author publications You can also search for this author inPubMed Google

Scholar * A Palmer View author publications You can also search for this author inPubMed Google Scholar * CJ Bulpitt View author publications You can also search for this author inPubMed 

Google Scholar CONSORTIA ON BEHALF OF THE GENERAL PRACTICE HYPERTENSION STUDY GROUP RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Grodzicki, T.,

Palmer, A., Bulpitt, C. _et al._ Incidence of diabetes and gout in hypertensive patients during 8 years of follow-up. _J Hum Hypertens_ 11, 583–585 (1997).

https://doi.org/10.1038/sj.jhh.1000496 Download citation * Issue Date: 01 September 1997 * DOI: https://doi.org/10.1038/sj.jhh.1000496 SHARE THIS ARTICLE Anyone you share the following link

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content-sharing initiative KEYWORDS * hypertension * gout * diabetes mellitus * diuretics