Polymorphisms in the leptin and leptin receptor genes in relation to resting metabolic rate and respiratory quotient in the québec family study

ABSTRACT BACKGROUND: Leptin (LEP) is an endocrine hormone that participates in many metabolic pathways, including those associated with the central regulation of energy homeostasis.

OBJECTIVE: We examined the associations between polymorphisms in the LEP and leptin receptor (LEPR) genes and resting metabolic rate (RMR) and respiratory quotient (RQ) in the Quebec Family

Study. METHODS AND SUBJECTS: Three polymorphisms in LEPR (K109R, Q223R and K656N) and one in LEP (19A>G) were genotyped in 678 subjects. RMR, RQ at rest and RQ while sitting, standing and

walking at 4.5 km/h (RQ45) were adjusted for age, sex, fat mass and fat-free mass. RESULTS: RQ45 was associated with the LEPR-K109R (_P_=0.004) and Q223R (_P_=0.03) polymorphisms, and RMR

showed association with the LEPR-K656N polymorphism (_P_=0.006). For the LEP-19A>G polymorphism, no significant associations were observed. However, LEP-A19A homozygotes who were carriers

of the LEPR N656 allele had a significantly lower RQ45 compared to other genotype combinations (_P_ for interaction=0.003). CONCLUSION: These findings suggest that DNA sequence variation in

the LEPR gene contributes to human variation in RMR and in the relative rates of substrate oxidation during low-intensity exercise in steady state but not in a resting state. Access through

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leptin–proopiomelanocortin pathway. _Proc Natl Acad Sci USA_ 2001; 98: 4233–4237. Article  CAS  Google Scholar  Download references ACKNOWLEDGEMENTS The Québec Family Study was supported by

multiple grants from the Medical Research Council of Canada and the Canadian Institutes for Health Research (PG-11811, MT-13960 and GR-15187). R Loos is supported by a postdoctoral

fellowship from the American Heart Association; Southeast affiliate (no. 0325355B). C Bouchard is partially supported by the George A Bray Chair in Nutrition. AUTHOR INFORMATION AUTHORS AND

AFFILIATIONS * Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA R J F Loos, T Rankinen & C Bouchard * Department of Psychiatry, Genetic Psychiatry,

Laval University Robert-Giffard Research Center, Beauport, Québec, Canada Y Chagnon * Department of Social and Preventive Medicine, Physical Activity Sciences Laboratory, Laval University,

Ste-Foy, Québec, Canada A Tremblay & L Pérusse Authors * R J F Loos View author publications You can also search for this author inPubMed Google Scholar * T Rankinen View author

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author publications You can also search for this author inPubMed Google Scholar * L Pérusse View author publications You can also search for this author inPubMed Google Scholar * C Bouchard

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THIS ARTICLE CITE THIS ARTICLE Loos, R., Rankinen, T., Chagnon, Y. _et al._ Polymorphisms in the leptin and leptin receptor genes in relation to resting metabolic rate and respiratory

quotient in the Québec Family Study. _Int J Obes_ 30, 183–190 (2006). https://doi.org/10.1038/sj.ijo.0803127 Download citation * Received: 15 December 2004 * Revised: 22 August 2005 *

Accepted: 29 August 2005 * Published: 11 October 2005 * Issue Date: 01 January 2006 * DOI: https://doi.org/10.1038/sj.ijo.0803127 SHARE THIS ARTICLE Anyone you share the following link with

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content-sharing initiative KEYWORDS * leptin * leptin receptor * resting metabolic rate * respiratory quotient