Dissociation of leptin and body weight in hyperthyroid patients after radioiodine treatment

ABSTRACT OBJECTIVE: Leptin regulates energy production rates and body weight, which are frequently altered in hyperthyroidism. Data on a possible interaction between leptin and thyroid

hormones are controversial. We assessed leptin serum concentrations, BMI, proportional fat tissue mass and thyroid hormones in hyperthyroid patients in a long-term follow-up after

radioiodine therapy. DESIGN: The study included 28 hyperthyroid patients (mean age 66 y) before and up to one y after radioiodine therapy. Leptin and thyroid hormones, general parameters,

BMI, proportional fat tissue (PFT) measurements by DEXA and thyroid morphology were recorded. Twenty-four age-matched euthyroid individuals (mean age 63 y) served as controls. RESULTS: At

baseline, leptin concentrations were significantly decreased in all hyperthyroid patients as compared to controls. One year after radioiodine therapy, 71% of the patients were euthyroid

(group A) and 29% remained hyperthyroid (group B). BMI and PFT increased in both groups. While leptin concentrations remained low in group B, they normalised in group A after 6 to 12 months.

Changes in leptin and thyroid hormone concentrations were positively correlated in group A patients (_r_=0.49, _P_=0.03) but not in patients remaining hyperthyroid. CONCLUSION: Our data

indicate a dissociation in the regulation of plasma leptin and BMI as well as proportional fat tissue in hyperthyroid patients which may be attributable to differences in lean and adipose

mass weight gain after radioiodine therapy or direct influences of thyroid hormones on leptin regulation. Access through your institution Buy or subscribe This is a preview of subscription

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Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Division of Endocrinology and Nuclear Medicine, Department of Internal Medicine,

Karl-Franzens University, Graz, Austria BM Obermayer-Pietsch, GE Frühauf & RW Lipp * Division of Diabetology and Metabolism, Department of Internal Medicine, Karl-Franzens University,

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author publications You can also search for this author inPubMed Google Scholar * TR Pieber View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING

AUTHOR Correspondence to BM Obermayer-Pietsch. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Obermayer-Pietsch, B., Frühauf, G., Lipp, R. _et al._

Dissociation of leptin and body weight in hyperthyroid patients after radioiodine treatment. _Int J Obes_ 25, 115–120 (2001). https://doi.org/10.1038/sj.ijo.0801479 Download citation *

Received: 05 January 2000 * Revised: 29 June 2000 * Accepted: 04 August 2000 * Published: 25 January 2001 * Issue Date: 01 January 2001 * DOI: https://doi.org/10.1038/sj.ijo.0801479 SHARE

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clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * leptin * thyroid hormones * hyperthyroidism * radioiodine therapy * body mass * weight change