Covid-19: french experts respond to new studies on long-term effects

French doctors have warned of “surprising” new studies that highlight the possible long-term effects and complications of Covid, including serious cardiovascular issues, and even increased

risk of dementia. The comments come following a series of peer-reviewed research studies into the long-term effects of Covid, including one by the University of Saint-Louis in the US,

published in the journal Nature, which showed that people who had contracted the virus had a greater risk of a range of conditions afterwards. In the worst cases, these included: “nervous

system and neurocognitive disorders, mental health disorders, metabolic disorders, cardiovascular disorders, gastrointestinal disorders, malaise, fatigue, musculoskeletal pain and anaemia.”

Although the risk of these health issues increases in people who have had Covid, it should be noted that the likelihood of their occurring is still very low. The study said its “results will

help to inform health system planning and the development of multidisciplinary care strategies to reduce chronic health loss among individuals with Covid-19.” CARDIOVASCULAR RISK Another

study, also published in Nature, showed a heightened risk of cardiac issues. Professor Ariel Cohen, cardiology expert and former president of the Société française de cardiologie, told

FranceInfo: “The results of these American researchers are a surprise.” He said that previously, doctors had thought that these conditions were only more represented among Covid patients

because people who were predisposed to these problems would declare them when they became infected. However, the new study shows “a risk multiplied by 1.5 or 2 for all events [medical

conditions]” not only the cardiac inflammations well known in Covid-19 patients [but also] the risk of stroke (multiplied by 1.52 in the year following infection), the risk of pulmonary

embolism (2.93) and that of acute coronary syndrome (1.72). "This study shows that there is an increased risk related to the infection itself and that it does not go away with time as

we thought,” said Professor Cohen. Dr Olivier Robineau, an infectious diseases specialist at Tourcoing hospital (Nord), said that the results corroborate his own observations, which is “that

the virus attacks the blood vessel walls”. NEUROLOGICAL AND KIDNEY PROBLEMS Another study, published in the Journal of the American Society of Nephrology showed that people who have

recovered from Covid are three times more at risk of developing kidney problems. This is largely because the virus causes vascular issues, which can affect the whole body. Prof Cohen said:

“All these organs are connected. As soon as the function of the artery is impaired, there is a risk that they will be affected.” Covid has also been found to affect the brain and nervous

system, causing not only a loss of taste and smell, but also longer-term effects such as “brain fog” and difficulty concentrating. One study published in Nature Communications showed damage

"that could lead to [these] long-term neurological symptoms of long Covid", even when the patient did not develop a severe form of the virus. Dr Robineau said: “[Covid] can lead to

these neurological symptoms in the long-term..and researchers are now alert to a risk of dementia.” Another study in the journal Science “raised the possibility that the infection may

accelerate or trigger the future development of neurodegenerative diseases such as Alzheimer's or Parkinson's”. Dr Robineau highlighted that this is less certain than the risk of

cardiovascular issues, and said that these conditions can take years to appear. Yet, another study, published in the British Medical Journal found that there was a 1.8 higher risk of

cognitive decline and a 1.39 higher risk of depression in the year after Covid infection. DIABETES ‘DISCOVERY’ Recent studies also suggest that the pandemic could cause “a legacy of chronic

illnesses” including Type 2 diabetes, another study, published in Nature, has suggested. The study found that “even mild SARS-CoV-2 infections can amplify a person’s chance of developing

diabetes, especially for those already susceptible to the disease”. This corroborated findings in another similar study, published in The Lancet, which suggested that people who have had

Covid have 40% more chance of developing Type 2 diabetes in the year afterwards. Eric Renard, vice-president of the Société francophone du diabète, told FranceInfo that this is because

“Covid-19 stresses the body, which can reveal latent diabetes”. He said that he does not believe that Covid itself causes diabetes, but simply enables it to become apparent in

already-susceptible people. “These patients will simply have discovered their diabetes in an unusual way,” he said. ‘STILL-RARE’ DISEASES Despite the proliferation of studies, Dr Robineau

has been careful to warn that “we must remain calm”. He said that while the studies show "an indisputable excess risk", they are “still rare events”. “We are not going to have an

epidemic of pulmonary embolisms,” he said, and added that smoking and a poor diet still carry far more risk when it comes to the development of cardiovascular issues. Dr Jérôme Larché,

regional head of monitoring Long Covid in the Occitanie region, said: “There is no reason to scare people for whom the infection has gone, and they feel perfectly well. All we need to do is

encourage them to see a GP if they have an issue.” He said that identifying people who have contracted long-term issues is already a “major challenge”. Prof Cohen added that another priority

is simply to “make up for the delay in treating many patients” whose medical interventions were delayed “because of the pandemic”. Further work is needed on the after-effects of Covid, as

these studies are still new and only focused on certain population types (men, veterans, older people). Similarly, while the studies suggest that long-term effects did affect some people who

contracted a mild form, the more severe effects are still found among those who had a severe form of the virus. This is good news for those who had a less-severe form of the virus since the

onset of Omicron. Yet, Dr Larché said that the studies highlight the ongoing importance of not getting infected if possible, and continuing to “use all possible levers to avoid being

contaminated, from vaccination to wearing a mask". He said: "Covid-19 is anything but a small, transient infection with no consequences." CURRENT COVID SITUATION IN FRANCE It

comes as recent figures suggest that France could be past the peak of the latest wave of the virus, and some doctors claim that the virus is largely “over” in the country (although others

disagree). READ MORE: CORONAVIRUS: DAILY UPDATES ON THE SITUATION IN FRANCE The latest situation on April 11, 2022, the latest official statistics available recorded at 14:00: * Recorded new

cases in France in previous 24 hours: 25,492 * New deaths: 178 (total number of deaths in France now 143,466) * Rate of positive tests: 32.1% * Number of people having received at least one

Covid-19 vaccine dose: 54,284,456 (+240 in the 24 hours to April 10 the date of the latest update) * Number of people having received three doses: 36,144,950 (+1,636 in the 24 hours to

April 10, the date of the latest update) RELATED ARTICLES IS FRANCE PAST THE PEAK OF COVID CASES? LATEST FIGURES IS COVID ‘OVER’ IN FRANCE? DOCTORS DISAGREE AND DEBATE FRANCE COVID: FOURTH

VACCINE DOSE NOW BEING OFFERED TO OVER-60S