The effect of maternal hyperglycemia on acid base balance and lung liquid production in the fetal sheep


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ABSTRACT ABSRACT.: In 10 chronically catheterized fetal sheep, the effects of 100g In 10 chronically catheterized fetal sheep, the effects of 100 g of glucose infused (intravenous) to the


pregnant ewe on lung liquid production and acid-base status were investigated. Maternal and fetal hyperglycemia occurred within 15 min of the infusion of glucose. There was a significant


increase in fetal PCO2 from 41.67 ± 1.00 to 46.89 ± 1.83 mm Hg and a decrease in fetal arterial pH from 7.42 ±0.016 to 7.33 ± 0.026 (_n_ = 7). This acidosis was probably the result of fetal


lactacidemia. There was also a decrease in fetal PO2 (_p_ < 0.001) following the infusion of glucose to the ewe. This, along with the acidosis, might account for the increased risk of


unexplained fetal death in the diabetic pregnancy especially near term. Following the infusion of glucose to the ewe there was an increase in maternal plasma osmolality by 16 ± 3.35


mosmol/kg (_n_ = 9) and in fetal plasma osmolality by 14 ± 2.64 mosmol/kg (_n_ = 9; _p_ < 0.001). Fetal lung liquid production fell from 0.195 ± 0.04 to 0.093 ± 0.02 ml/min (_n_ = 6; _p_


< 0.001). There was no change in the excretion of osmol by the lungs. The decreased lung liquid production was probably due to a decrease in the net movement of fluid across the pulmonary


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ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * School of Physiology and Pharmacology, University of New South Wales, Sydney, New South Wales, Australia Francine G Smith & 


Eugenie R Lumbers Authors * Francine G Smith View author publications You can also search for this author inPubMed Google Scholar * Eugenie R Lumbers View author publications You can also


search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Smith, F., Lumbers, E. The Effect of Maternal


Hyperglycemia on Acid Base Balance and Lung Liquid Production in the Fetal Sheep. _Pediatr Res_ 22, 355–359 (1987). https://doi.org/10.1203/00006450-198709000-00023 Download citation *


Received: 14 November 1986 * Accepted: 27 April 1987 * Issue Date: 01 September 1987 * DOI: https://doi.org/10.1203/00006450-198709000-00023 SHARE THIS ARTICLE Anyone you share the following


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