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ABSTRACT ABSTRACT: Somatomedins/insulin-like growth factors (Sm/IGFs) are present in blood and in extracts from multiple tissues of the human fetus and induce the proliferation of cultured
human fetal cells. To identify the cellular location of immunoreactive Sm/IGF in human fetal tissues, we have performed immunocytochemistry in tissues from prostaglandin-induced human fetal
abortuses of 12 to 20 wk in gestation. Every tissue studied except the cerebral cortex contains Sm/IGF immunoreactive cells. Cells staining positively include hepatocytes, hepatic
hemopoietic cells, columnar epithelia of the pulmonary airways, intestine and kidney tubules, adrenal cortical cells, dermal cells, skeletal and cardiac muscle fibers, and pancreatic islet
and acinar cells. Immunostaining was specific for Sm/IGFs, but because of the cross-reactivity of the antibodies it was not possible to determine whether the immunoreactivity represented
Sm-C/IGF I, IGF II, or both. Liver contained the greatest proportion of immunoreactive cells, while the thymus and spleen had only a few immunostained cells. With the possible exception of
dermal and some adrenal cortical cells, the immunoreactive cells do not appear to be the primary sites of Sm/IGF synthesis, because parallel in situ hybridization histochemical studies using
Sm/IGF oligodeoxyribonucleotide probes show that Sm/IGF mRNAs are localized predominantly to fibroblasts and mesenchymal cells. Therefore the immunoreactive cells identified in this study
may define sites of action of Sm/IGFs. SIMILAR CONTENT BEING VIEWED BY OTHERS NESFATIN-1 AND NESFATIN-1-LIKE PEPTIDE SUPPRESS GROWTH HORMONE SYNTHESIS VIA THE AC/PKA/CREB PATHWAY IN
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AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Departments of Pediatrics, The University of Worth Carolina, Chapel Hill, 27514, NC Victor K M Han, Louis E Underwood & A Joseph
D'Ercole * Anatomy, The University of Worth Carolina, Chapel Hill, 27514, NC Andrew C Towle & Jean M Lauder * Department of Paediatrics, The University of Sheffield, Northern
General Hospital, Sheffield, S57 AV, England David J Hill & Alastair J Strain Authors * Victor K M Han View author publications You can also search for this author inPubMed Google
Scholar * David J Hill View author publications You can also search for this author inPubMed Google Scholar * Alastair J Strain View author publications You can also search for this author
inPubMed Google Scholar * Andrew C Towle View author publications You can also search for this author inPubMed Google Scholar * Jean M Lauder View author publications You can also search for
this author inPubMed Google Scholar * Louis E Underwood View author publications You can also search for this author inPubMed Google Scholar * A Joseph D'Ercole View author
publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Han, V., Hill, D., Strain, A.
_et al._ Identification of Somatomedin/Insulin-Like Growth Factor Immunoreactive Cells in the Human Fetus. _Pediatr Res_ 22, 245–249 (1987). https://doi.org/10.1203/00006450-198709000-00001
Download citation * Received: 26 January 1987 * Accepted: 27 March 1987 * Issue Date: 01 September 1987 * DOI: https://doi.org/10.1203/00006450-198709000-00001 SHARE THIS ARTICLE Anyone you
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