525 increased dietary zinc and the outcome of pregnancy in magnesium (mg) deficient rat dams


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ABSTRACT The dietary requirement for Mg and zinc (Zn) increase during gestation; both are essential for protein synthesis and growth. The nutrient requirement for gestation in laboratory


rats are 0.04% for Mg and 12 mg/kg (ppm) for Zn (Nat. Res. Council, 1978). We fed day 2 pregnant Sprague-Dawley rat dams purified diets with 24% casein, 0.15% or 0.006% Mg, and three levels


of Zn: approx. 10 ×, 2 ×, and 1.5 × the level of 12 ppm throughout gestation (N= 3 dams/group). All diets and tissues were analyzed using an atomic absorption spectrophotometer. US Bureau


Stds. liver ref. was used. Rat pups/group analyzed: N=6-11. On day 2, the first group of rat pups had 83.4% water, compared with 86.7 % in the second, Mg-deficient group (P<0.001), and


the Zn in Mg-fed first group was Tower than in the Mg-deficient group (124.2±2.6 vs. 143.6±5.8; P<0.005). It is concluded that increased dietary Zn has an ameliorative effect on pregnancy


in Mg deficient rat dams, and that the tissue content of water in the deficient pups is significantly ino reased. Support: Life Seekers and SLU Dept. Ped, CGMH. ARTICLE PDF AUTHOR


INFORMATION AUTHORS AND AFFILIATIONS * St. Louis U. Sch. Med. and Cardinal Glennon Hosp., Dept. Pediat-Adolesc. Med, St. Louis, MO Joan L Caddell & Patricia Monteleone Authors * Joan L


Caddell View author publications You can also search for this author inPubMed Google Scholar * Patricia Monteleone View author publications You can also search for this author inPubMed 


Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Caddell, J., Monteleone, P. 525 INCREASED DIETARY ZINC AND THE OUTCOME OF PREGNANCY IN


MAGNESIUM (Mg) DEFICIENT RAT DAMS. _Pediatr Res_ 15 (Suppl 4), 528 (1981). https://doi.org/10.1203/00006450-198104001-00538 Download citation * Issue Date: 01 April 1981 * DOI:


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