Clearing away the debris | Nature Reviews Neuroscience


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Access through your institution Buy or subscribe Damaged mitochondria are cleared from neurons by mitophagy. At the soma, this process is mediated by lysosomes and requires two


Parkinson's disease-related proteins, parkin and PINK1. However, it remains controversial whether the same mechanisms operate in distal axons where lysosomes are sparse. The authors


showed that damage to mitochondria in the distal axons of hippocampal neurons caused recruitment of PINK1 and parkin, which act locally to mediate mitophagy. Knockout of either protein


prevented mitophagy in damaged hippocampal axons. These findings implicate the PINK1–parkin pathway in the response of distal axons to mitochondrial damage. This is a preview of subscription


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ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Ashrafi, G. et al. Mitophagy of damaged mitochondria occurs


locally in distal neuronal axons and requires PINK1 and Parkin. _J. Cell Biol._ 206, 655–670 (2014) Article  CAS  Google Scholar  Download references Authors * Sian Lewis View author


publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Lewis, S. Clearing away the


debris. _Nat Rev Neurosci_ 15, 632 (2014). https://doi.org/10.1038/nrn3832 Download citation * Published: 19 September 2014 * Issue Date: October 2014 * DOI: https://doi.org/10.1038/nrn3832


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